Claim

Sex-specific biological aging clocks predicted systemic diseases and all-cause mortality in sex-dependent and organ-dependent ways in longitudinal survival analyses.

Type COMPARATIVE · truth-evaluable: yes · status at snapshot: ACTIVE · created seq 19850 · qualifiers {"population":"Longitudinal human survival analyses using sex-specific, organ-resolved aging clocks."}

a conjunction joins clauses that may be separately evaluable

Referenced 108 times: checked 2, looked up by assistants 0, viewed 70, shared 36. A count of attention, not evidence.

Topics

Medicine · 1efd24fe Health · 1efd24fe

Assessment

Supported

Score: 0.9892 under ledger-default@0.3.0 at snapshot 27745

3 of 4 review checks done · 1 counted · 2 by the author only

3 independent evidence lineages · review checks 1 of 4 · stability HIGH

Main unresolved issue: 4 counted evidence items have no independence review; repeats of one origin may be counted as several coverage:6b825aef-833a-8631-b7e5-48aecc3f1d86

Not yet independently audited.Evidence reviewed so far supports this claim, but only 1 of 4 review checks has been done.A quoted passage from news-medical.net was not found on the page when Galedra fetched it.

Why?

Strongest counted support: The abstract reports that sex-specific clocks predict systemic diseases and all-cause mortality in sex-dependent and organ-dependent ways. weight 1.800000 evidence

Suppressed as dependent: The abstract reports sex- and organ-dependent prediction of systemic disease and all-cause mortality.

Review gaps: qualifiers reviewed, opposing search done, independence reviewed

What would most change this: One independent, direct measurement that contradicts this claim would move it from Supported to Supported.

Hide calculation

0.9892 under ledger-default@0.3.0 at snapshot 27745 · state Supported · Review checks: 1 of 4 · stability HIGH · 4 sources, 3 independent lineages

Model ledger-default@0.3.0 (the default model, not the answer) · snapshot 27745 · trace sha256:a6c4f823883e6f6db695d5cd98f6fdd7bb45861eb8fe6355c6e946b3c8ae15e1

Last changed at entry seq 24318; nothing logged since has borne on this claim.

How the number was reached

Each counted link is weighed by multiplying the factors the model declares; a factor it does not declare is not shown. Every factor name below links to what that number means.

Link	Working	Weight	Counted as
32d1157b support	relevance DIRECT 2.0 × observation DIRECT_TEXT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	1.800000	1.800000
8c97678f support	relevance STRONG 1.2 × observation DIRECT_TEXT 0.9 × interpretation 1 step, 1 − 0.15 × 1 0.850000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	0.918000	0.918000
b98b6cbd support	relevance DIRECT 2.0 × observation MODEL_OUTPUT 0.0 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	0.000000	0.000000 (dependent strongest only, kept f469b06e)
f469b06e support	relevance DIRECT 2.0 × observation DIRECT_TEXT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	1.800000	1.800000

prior 0.50 → log-odds 0.000000 + 4.518000 (the counted weights) = 4.518000 → probability 0.9892

Under neighbouring settings of the same model: 0.9594 to 0.9972, a spread of 0.0378.

Half-even rounding, six places for weights and four for the probability. The same inputs under the same model reproduce this exactly; that is what the trace hash above is for. How a score is worked out explains every factor, why it is there, and what the model sets it to.

Your view

Registered views

Nobody has registered a view yet.

Registered views are personal belief, not evidence: they never change Galedra's assessment. Affiliations are self-declared and shown only for groups of 5 or more.

Checked as part of

Statements this claim was broken out of. The claim is scored on its own; a statement's reading only counts its claims.

“Sex-specific biological aging clocks predicted systemic diseases and all-cause mortality in sex-dependent and organ-dependent ways in longitudinal survival...” · 1 claim · 29 September 2026
“A Nature Medicine study developed 38 sex-specific biological aging clocks across 15 organ systems and found divergent female and male aging signatures, with...” · 2 claims · 29 September 2026

Evidence for

The abstract reports sex- and organ-dependent prediction of systemic disease and all-cause mortality.

From Sex-specific biological aging clocks across organs and omics Read 2026-09-29 Relevance DIRECT Steps 0 Counted
The secondary report corroborates that sex-specific aging clocks were associated with mortality and sex-differentiated progression from mild cognitive impairment to Alzheimer’s disease.

From Sex-specific biological clocks reveal how aging differs across the body in women and men Read 2026-09-29 Relevance STRONG Steps 1 Counted

Secondary reporting of the same Nature Medicine study; corroborating article, not an independent aging cohort.
The supplied abstract directly states that sex-specific clocks predicted systemic disease and all-cause mortality in sex- and organ-dependent ways.

From Sex-specific biological aging clocks across organs and omics Read 2026-09-29 Relevance DIRECT Steps 0 Counted

The excerpt repeats the target claim's prediction result nearly verbatim.
The abstract reports that sex-specific clocks predict systemic diseases and all-cause mortality in sex-dependent and organ-dependent ways.

From Sex-specific biological aging clocks across organs and omics Read 2026-09-29 Relevance DIRECT Steps 0 Counted

Evidence against

None.

Qualifications

None.

Suppressed as dependent

Evidence	Group	Kept instead
9f43fc6e		f469b06e

Inferences

Concluded from

None.

Used as a premise in

None.

An inference is interpretation, not evidence: it never changes the assessment of its conclusion. Each premise is a claim with its own evidence.

Threads

None. Threads are for disagreements about how a determination was made — a statement whose figures are not in the passage it rests on, two sources that may share an origin. Something about the world belongs in the evidence above.

Claim edges

None. Edges are stored and displayed; v0.1 does not propagate probability across them.

Review checklist

Review checks: 1 of 4

3 checks by this claim's own author, alongside the independent review above. 1 OPPOSING EVIDENCE SEARCH · 1 QUALIFIER CHECK · 1 EVIDENCE VERIFICATION. A check by the person who recorded a claim does not raise its review coverage.

Check	Done	By
qualifiers reviewed	no
opposing search done	no
independence reviewed	no
primary source reviewed	yes	b98b6cbd, f469b06e

Summary

Supported. The main support is: The abstract reports that sex-specific clocks predict systemic diseases and all-cause mortality in sex-dependent and organ-dependent ways. 173223ee

1 further item repeats the same origin and is not independent evidence. 9f43fc6e

A search for evidence in the opposing direction found something; see the counted evidence. 2597ef9d

Review checks: 1 of 4. coverage:6b825aef-833a-8631-b7e5-48aecc3f1d86

Generated by stub-v0.1; every sentence cites graph ids.

Contribution history

seq	event	detail
19850	APPENDED
19851	ACCEPT	AUTOMATIC_AFTER_VALIDATION
19860	LINK_EVIDENCE	by 1efd24fe (accepted)
19874	LINK_EVIDENCE	by 1efd24fe (accepted)
22012	TASK_RESULT	by 1efd24fe (accepted)
24317	TASK_RESULT	by 1efd24fe (accepted)

Score trace

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  "variants": {
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    "permissive": "0.9972",
    "conservative": "0.9594"
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  "code_hash": "sha256:c61a6fdf35a754a0d7e958df149036a083c0eaeb7d2d2e52704ec32b0c36def7",
  "contested": false,
  "stability": "HIGH",
  "claim_type": "COMPARATIVE",
  "config_hash": "sha256:86768038080b8ab5233f1e4b7aba10af05b5bb44caa432095150b90e81209809",
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  "snapshot_seq": 24318,
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  "support_groups": 3,
  "model_dependent": false,
  "review_coverage": "0.25",
  "truth_evaluable": true,
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  "contradict_groups": 0,
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