Claim

In pregnant female mice, increased SK3 activity in dorsal-raphe serotonin neurons reduced firing and promoted food-craving-like behavior; deleting SK3 reduced that behavior.

Type CAUSAL · truth-evaluable: yes · status at snapshot: ACTIVE · created seq 25106 · qualifiers {"population":"Pregnant and virgin female mice","time_range":"Pregnancy-associated behavioral and neuronal measurements reported in the 2026 Nature Neuroscience study","translation":"The evidence is from mice and does not establish the same mechanism in humans"}

a conjunction joins clauses that may be separately evaluable

Referenced 186 times: checked 1, looked up by assistants 0, viewed 139, shared 46. A count of attention, not evidence.

Topics

Neuroscience · 1efd24fe

Assessment

Leans supported

Score: 0.6550 under ledger-default@0.3.0 at snapshot 27745

3 of 4 review checks done · 1 counted · 2 by the author only

2 independent evidence lineages · review checks 1 of 4 · stability LOW

Main unresolved issue: 5 counted evidence items have no independence review; repeats of one origin may be counted as several coverage:6e4c4cea-7954-86c2-b621-da5d3f7f722c

Not yet independently audited.Evidence points both ways.This assessment depends heavily on modeling choices.Every quoted passage was confirmed on the page when Galedra fetched it.

Related: NARROWS incoming: Supported

Why?

Strongest counted support: The mouse study links increased SK3 activity in dorsal-raphe serotonin neurons to reduced firing and pregnancy-associated food-craving-like behavior, while SK3 deletion reduces it. weight 1.800000 evidence

Strongest counted contradiction: An earlier mouse study directly linked pregnancy food-craving-like events to dynamic accumbal D2-receptor dopaminergic signaling. weight 0.540000 evidence

Suppressed as dependent: The excerpt reports pregnancy-associated firing suppression, SK3 knockout reducing craving-like behavior, and SK3 overexpression mimicking the behavior.

Review gaps: qualifiers reviewed, opposing search done, independence reviewed

What would most change this: One independent, direct measurement that contradicts this claim would move it from Leans supported to Leans contradicted.

Hide calculation

0.6550 under ledger-default@0.3.0 at snapshot 27745 · state Leans supported · Review checks: 1 of 4 · stability LOW · 5 sources, 2 independent lineages

Model ledger-default@0.3.0 (the default model, not the answer) · snapshot 27745 · trace sha256:02ec284943e1bbffba8aab2768c718c69c1e99a5cd0471fc0bc8069b14cafc46

Last changed at entry seq 25256; nothing logged since has borne on this claim.

How the number was reached

Each counted link is weighed by multiplying the factors the model declares; a factor it does not declare is not shown. Every factor name below links to what that number means.

Link	Working	Weight	Counted as
e5964397 support	relevance DIRECT 2.0 × observation DIRECT_TEXT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	1.800000	0.000000 (dependent strongest only, kept 8bedf6fa)
76e43c93 qualify	relevance DIRECT 2.0 × observation DIRECT_TEXT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	1.800000	0.000000 (non directional)
8bedf6fa support	relevance DIRECT 2.0 × observation DIRECT_TEXT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	1.800000	1.800000
aafc479d qualify	relevance DIRECT 2.0 × observation DIRECT_TEXT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	1.800000	0.000000 (non directional)
5527a804 contradict	relevance MODERATE 0.6 × observation DIRECT_TEXT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	0.540000	0.540000

prior 0.35 → log-odds -0.619039 + 1.260000 (the counted weights) = 0.640961 → probability 0.6550

Under neighbouring settings of the same model: 0.5654 to 0.7348, a spread of 0.1694.

Half-even rounding, six places for weights and four for the probability. The same inputs under the same model reproduce this exactly; that is what the trace hash above is for. How a score is worked out explains every factor, why it is there, and what the model sets it to.

Your view

Registered views

Nobody has registered a view yet.

Registered views are personal belief, not evidence: they never change Galedra's assessment. Affiliations are self-declared and shown only for groups of 5 or more.

Checked as part of

Statements this claim was broken out of. The claim is scored on its own; a statement's reading only counts its claims.

“In pregnant female mice, increased SK3 activity in dorsal-raphe serotonin neurons reduced firing and promoted food-craving-like behavior; deleting SK3...” · 1 claim · 29 September 2026

Evidence for

The mouse study links increased SK3 activity in dorsal-raphe serotonin neurons to reduced firing and pregnancy-associated food-craving-like behavior, while SK3 deletion reduces it.

From Serotonin neurons in the dorsal raphe control food-craving-like behavior during pregnancy in mice Read 2026-09-29 Relevance DIRECT Steps 0 Counted

The primary abstract directly reports the neuronal manipulation and behavioral effects; human relevance remains untested.
The excerpt reports pregnancy-associated firing suppression, SK3 knockout reducing craving-like behavior, and SK3 overexpression mimicking the behavior.

From Serotonin neurons in the dorsal raphe control food-craving-like behavior during pregnancy in mice Read 2026-09-29 Relevance DIRECT Steps 0 Counted

Evidence against

An earlier mouse study directly linked pregnancy food-craving-like events to dynamic accumbal D2-receptor dopaminergic signaling.

From Food craving-like episodes during pregnancy are mediated by accumbal dopaminergic circuits Read 2026-09-29 Relevance MODERATE Steps 0 Counted

This independent primary study identifies an accumbal D2R circuit as directly modulating pregnancy food-craving-like events, limiting any interpretation that the SK3 dorsal-raphe pathway is the sole mechanism.

Qualifications

The study’s pregnancy comparisons used G14 female mice and BioDAQ food-craving-like behavior measurements.

From Serotonin neurons in the dorsal raphe control food-craving-like behavior during pregnancy in mice Read 2026-09-29 Relevance DIRECT Steps 0 Counted

The primary evidence narrows the pregnancy model to gestational day 14 and a specific assay context.
The behavioral endpoint used highly palatable, high-fat, or high-sucrose diet craving-like assays.

From Serotonin neurons in the dorsal raphe control food-craving-like behavior during pregnancy in mice Read 2026-09-29 Relevance DIRECT Steps 0 Counted

The reported behavior is an operationalized mouse craving-like assay involving palatable diets, not a direct human clinical measure.

Suppressed as dependent

Evidence	Group	Kept instead
323a29cd		8bedf6fa

Inferences

Concluded from

None.

Used as a premise in

None.

An inference is interpretation, not evidence: it never changes the assessment of its conclusion. Each premise is a claim with its own evidence.

Threads

None. Threads are for disagreements about how a determination was made — a statement whose figures are not in the passage it rests on, two sources that may share an origin. Something about the world belongs in the evidence above.

Claim edges

From	Relationship	To
ceaca1ea	NARROWS	3f7f722c

Review checklist

Review checks: 1 of 4

3 checks by this claim's own author, alongside the independent review above. 1 OPPOSING EVIDENCE SEARCH · 1 QUALIFIER CHECK · 1 EVIDENCE VERIFICATION. A check by the person who recorded a claim does not raise its review coverage.

Check	Done	By
qualifiers reviewed	no
opposing search done	no
independence reviewed	no
primary source reviewed	yes	e5964397, 76e43c93, 8bedf6fa, aafc479d, 5527a804

Summary

Leans supported. The main support is: The mouse study links increased SK3 activity in dorsal-raphe serotonin neurons to reduced firing and pregnancy-associated food-craving-like behavior, while SK3 deletion reduces it. 3704bfc5

Against that, contradiction: An earlier mouse study directly linked pregnancy food-craving-like events to dynamic accumbal D2-receptor dopaminergic signaling. d8295b65

1 further item repeats the same origin and is not independent evidence. 323a29cd

Qualifier: The study’s pregnancy comparisons used G14 female mice and BioDAQ food-craving-like behavior measurements. 5f53cda3

Qualifier: The behavioral endpoint used highly palatable, high-fat, or high-sucrose diet craving-like assays. 4b7cdabc

A narrower version of this claim is supported. ceaca1ea

Generated by stub-v0.1; every sentence cites graph ids.

Contribution history

seq	event	detail
25106	APPENDED
25107	ACCEPT	AUTOMATIC_AFTER_VALIDATION
25112	LINK_EVIDENCE	by 1efd24fe (accepted)
25141	TASK_RESULT	by 1efd24fe (accepted)
25201	TASK_RESULT	by 1efd24fe (accepted)
25255	TASK_RESULT	by 1efd24fe (accepted)

Score trace

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