Claim

In mice grafted with human diffuse midline gliomas, levetiracetam slowed malignant-cell growth.

Type OBSERVATIONAL · truth-evaluable: yes · status at snapshot: ACTIVE · created seq 13494

Referenced 132 times: checked 2, looked up by assistants 0, viewed 87, shared 43. A count of attention, not evidence.

Topics

Medicine · 1efd24fe Health · 1efd24fe

Assessment

Supported

Score: 0.9781 under ledger-default@0.3.0 at snapshot 27745

3 of 4 review checks done · 1 counted · 2 by the author only

2 independent evidence lineages · review checks 1 of 4 · stability HIGH

Main unresolved issue: 3 counted evidence items have no independence review; repeats of one origin may be counted as several coverage:8aaadb1a-d88a-8163-ba14-ce8c76033e66

Not yet independently audited.Evidence reviewed so far supports this claim, but only 1 of 4 review checks has been done.A quoted passage from med.stanford.edu was not found on the page when Galedra fetched it.

Why?

Strongest counted support: Stanford reports tumor-growth slowing in diffuse midline glioma mice and a survival association limited to diffuse midline glioma patients. weight 2.000000 evidence

Suppressed as dependent: The excerpt directly states that levetiracetam slowed malignant-cell growth in mice with human diffuse midline glioma grafts.

Review gaps: qualifiers reviewed, opposing search done, independence reviewed

What would most change this: One independent, direct measurement that contradicts this claim would move it from Supported to Supported.

Hide calculation

0.9781 under ledger-default@0.3.0 at snapshot 27745 · state Supported · Review checks: 1 of 4 · stability HIGH · 3 sources, 2 independent lineages

Model ledger-default@0.3.0 (the default model, not the answer) · snapshot 27745 · trace sha256:d581d37413baf145de8c63c5d0b870e50c34d284b0204fb68583a39269b0e48f

Last changed at entry seq 13916; nothing logged since has borne on this claim.

How the number was reached

Each counted link is weighed by multiplying the factors the model declares; a factor it does not declare is not shown. Every factor name below links to what that number means.

Link	Working	Weight	Counted as
025e0cdf support	relevance DIRECT 2.0 × observation DIRECT_TEXT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	1.800000	0.000000 (dependent strongest only, kept de0090f7)
f638d597 support	relevance DIRECT 2.0 × observation DIRECT_TEXT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	1.800000	1.800000
de0090f7 support	relevance DIRECT 2.0 × observation MEASUREMENT 1.0 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	2.000000	2.000000

prior 0.50 → log-odds 0.000000 + 3.800000 (the counted weights) = 3.800000 → probability 0.9781

Under neighbouring settings of the same model: 0.9346 to 0.9929, a spread of 0.0583.

Half-even rounding, six places for weights and four for the probability. The same inputs under the same model reproduce this exactly; that is what the trace hash above is for. How a score is worked out explains every factor, why it is there, and what the model sets it to.

Your view

Registered views

Nobody has registered a view yet.

Registered views are personal belief, not evidence: they never change Galedra's assessment. Affiliations are self-declared and shown only for groups of 5 or more.

Checked as part of

Statements this claim was broken out of. The claim is scored on its own; a statement's reading only counts its claims.

“In mice grafted with human diffuse midline gliomas, levetiracetam slowed malignant-cell growth.” · 1 claim · 28 September 2026
“Stanford researchers reported that levetiracetam slowed diffuse midline glioma growth in mice and was linked to longer survival in patients with diffuse...” · 2 claims · 28 September 2026

Evidence for

Stanford reports tumor-growth slowing in diffuse midline glioma mice and a survival association limited to diffuse midline glioma patients.

From Anti-seizure drug fights aggressive childhood brain tumors, Stanford Medicine-led study shows Read 2026-09-28 Relevance DIRECT Steps 0 Counted

The passage directly reports slowed growth in the diffuse midline glioma mouse model.
The Nature Medicine study reports reduced proliferation and tumor burden with extended survival in DMG-bearing mice, but not in hemispheric high-grade glioma xenografts.

From Levetiracetam therapeutically targets GABAergic synapses in diffuse midline glioma Read 2026-09-28 Relevance DIRECT Steps 0 Counted

Peer-reviewed primary evidence directly corroborates the animal-model claim and its tumor-subtype limitation.
The excerpt directly states that levetiracetam slowed malignant-cell growth in mice with human diffuse midline glioma grafts.

From Anti-seizure drug fights aggressive childhood brain tumors, Stanford Medicine-led study shows Read 2026-09-28 Relevance DIRECT Steps 0 Counted

The passage directly matches the claim and contrasts it with no slowing in hemispheric high-grade glioma mice.

Evidence against

None.

Qualifications

None.

Suppressed as dependent

Evidence	Group	Kept instead
426e69c5		de0090f7

Inferences

Concluded from

None.

Used as a premise in

None.

An inference is interpretation, not evidence: it never changes the assessment of its conclusion. Each premise is a claim with its own evidence.

Threads

None. Threads are for disagreements about how a determination was made — a statement whose figures are not in the passage it rests on, two sources that may share an origin. Something about the world belongs in the evidence above.

Claim edges

None. Edges are stored and displayed; v0.1 does not propagate probability across them.

Review checklist

Review checks: 1 of 4

3 checks by this claim's own author, alongside the independent review above. 1 OPPOSING EVIDENCE SEARCH · 1 QUALIFIER CHECK · 1 EVIDENCE VERIFICATION. A check by the person who recorded a claim does not raise its review coverage.

Check	Done	By
qualifiers reviewed	no
opposing search done	no
independence reviewed	no
primary source reviewed	yes	025e0cdf, f638d597, de0090f7

Summary

Supported. The main support is: The Nature Medicine study reports reduced proliferation and tumor burden with extended survival in DMG-bearing mice, but not in hemispheric high-grade glioma xenografts. 85e58bf7

1 further item repeats the same origin and is not independent evidence. 426e69c5

A search for evidence in the opposing direction found none. 740cb7a3

Review checks: 1 of 4. coverage:8aaadb1a-d88a-8163-ba14-ce8c76033e66

Generated by stub-v0.1; every sentence cites graph ids.

Contribution history

seq	event	detail
13494	APPENDED
13495	ACCEPT	AUTOMATIC_AFTER_VALIDATION
13504	LINK_EVIDENCE	by 1efd24fe (accepted)
13524	LINK_EVIDENCE	by 1efd24fe (accepted)
13534	TASK_RESULT	by 1efd24fe (accepted)

Score trace

{
  "claim": "8aaadb1a-d88a-8163-ba14-ce8c76033e66",
  "links": [
    {
      "kept": "f4285319-487f-845b-acd9-039ede0090f7",
      "link": "47e6092b-25e9-8d61-9d2e-4219025e0cdf",
      "group": null,
      "reason": "dependent_strongest_only",
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "5d18f7c0-d4e4-8dd3-b180-68a9426e69c5",
      "direction": "SUPPORT",
      "magnitude": "1.800000",
      "relevance": "DIRECT",
      "extraction": "UNVERIFIED",
      "provenance": "INDEPENDENT",
      "observation": "DIRECT_TEXT",
      "source_type": "PRIMARY_TEXT",
      "authenticity": "UNVERIFIED",
      "audit_confirmed": false,
      "effective_weight": "0.000000",
      "interpretive_steps": 0
    },
    {
      "link": "c690e891-ada8-81e3-8994-b795f638d597",
      "group": null,
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "870905c0-0deb-893b-91a0-b54d85e58bf7",
      "direction": "SUPPORT",
      "magnitude": "1.800000",
      "relevance": "DIRECT",
      "extraction": "UNVERIFIED",
      "provenance": "INDEPENDENT",
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      "source_type": "PRIMARY_TEXT",
      "authenticity": "UNVERIFIED",
      "audit_confirmed": false,
      "effective_weight": "1.800000",
      "interpretive_steps": 0
    },
    {
      "link": "f4285319-487f-845b-acd9-039ede0090f7",
      "group": null,
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "739fae63-4205-80e6-8192-b16183400e07",
      "direction": "SUPPORT",
      "magnitude": "2.000000",
      "relevance": "DIRECT",
      "extraction": "UNVERIFIED",
      "provenance": "INDEPENDENT",
      "observation": "MEASUREMENT",
      "source_type": "PRIMARY_TEXT",
      "authenticity": "UNVERIFIED",
      "audit_confirmed": false,
      "effective_weight": "2.000000",
      "interpretive_steps": 0
    }
  ],
  "model": "ledger-default@0.3.0",
  "prior": "0.50",
  "variants": {
    "spread": "0.0583",
    "permissive": "0.9929",
    "conservative": "0.9346"
  },
  "code_hash": "sha256:c61a6fdf35a754a0d7e958df149036a083c0eaeb7d2d2e52704ec32b0c36def7",
  "contested": false,
  "stability": "HIGH",
  "claim_type": "OBSERVATIONAL",
  "config_hash": "sha256:86768038080b8ab5233f1e4b7aba10af05b5bb44caa432095150b90e81209809",
  "probability": "0.9781",
  "provisional": true,
  "evidence_sum": "3.800000",
  "snapshot_seq": 13916,
  "prior_log_odds": "0.000000",
  "support_groups": 2,
  "model_dependent": false,
  "review_coverage": "0.25",
  "truth_evaluable": true,
  "assessment_state": "SUPPORTED",
  "review_checklist": {
    "qualifiers_reviewed": {
      "by": [],
      "ok": false
    },
    "opposing_search_done": {
      "by": [],
      "ok": false
    },
    "independence_reviewed": {
      "by": [],
      "ok": false
    },
    "primary_source_reviewed": {
      "by": [
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        "c690e891-ada8-81e3-8994-b795f638d597",
        "f4285319-487f-845b-acd9-039ede0090f7"
      ],
      "ok": true
    }
  },
  "contradict_groups": 0,
  "rounding_boundary": false,
  "posterior_log_odds": "3.800000",
  "not_applicable_reason": null,
  "independence_unreviewed": 3
}