Claim

In the AMP trials, prophylactic VRC01 selected de novo HIV escape mutations in 8 of 26 treated participants but none of 21 placebo participants; several mutations caused cross-resistance, while N6 and 1–18 largely retained activity.

Type QUANTITATIVE · truth-evaluable: yes · status at snapshot: ACTIVE · created seq 18812

35 words; atomic claims are usually under 25a conjunction joins clauses that may be separately evaluablea comma-separated series may list several propositions

Referenced 137 times: checked 3, looked up by assistants 0, viewed 94, shared 40. A count of attention, not evidence.

Topics

Vaccines · 1efd24fe Biology · 1efd24fe

Assessment

Insufficient evidence

3 of 4 review checks done · 1 counted · 2 by the author only

0 independent evidence lineages · review checks 1 of 4 · stability n/a

Main unresolved issue: 5 counted evidence items have no independence review; repeats of one origin may be counted as several coverage:8d343107-f7d5-8b80-8b39-5a5bfc4c6343

Not yet independently audited.A quoted passage from nature.com was not found on the page when Galedra fetched it.

Why?

Suppressed as dependent: The passage directly reports the treated and placebo counts, cross-resistance, and retained activity of N6 and 1–18.; The AMP analysis found de novo VRC01 escape in 8 of 26 treated participants versus none of 21 placebo participants, with cross-resistance while N6 and 1–18 largely retained activity.

Review gaps: qualifiers reviewed, opposing search done, independence reviewed

What would most change this: One independent, direct measurement that supports this claim would move it from Insufficient evidence to Supported.

Hide calculation

No probability. No counted evidence bears on this claim at this snapshot.

Model ledger-default@0.3.0 (the default model, not the answer) · snapshot 27745 · trace sha256:85189750485a0ab2e107d8145f37bf084385bb27d052b6b0a785a3a7670d7ea9

Last changed at entry seq 24308; nothing logged since has borne on this claim.

How the number was reached

Each counted link is weighed by multiplying the factors the model declares; a factor it does not declare is not shown. Every factor name below links to what that number means.

Link	Working	Counted as
1bbfc723 support	relevance DIRECT 2.0 × observation DIRECT_TEXT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance SELF 0.0 × edition NAMED_OR_UNRELATED 1	0.000000
52d299f1 support	relevance DIRECT 2.0 × observation DATASET_RESULT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance SELF 0.0 × edition NAMED_OR_UNRELATED 1	0.000000
5ab26286 support	relevance DIRECT 2.0 × observation DIRECT_TEXT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance SELF 0.0 × edition NAMED_OR_UNRELATED 1	0.000000 (dependent strongest only, kept 52d299f1)
b5b98ed8 support	relevance DIRECT 2.0 × observation DIRECT_TEXT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance SELF 0.0 × edition NAMED_OR_UNRELATED 1	0.000000 (dependent strongest only, kept cb36780f)
cb36780f support	relevance DIRECT 2.0 × observation DIRECT_TEXT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance SELF 0.0 × edition NAMED_OR_UNRELATED 1	0.000000

prior — → log-odds —

Half-even rounding, six places for weights and four for the probability. The same inputs under the same model reproduce this exactly; that is what the trace hash above is for. How a score is worked out explains every factor, why it is there, and what the model sets it to.

Your view

Registered views

Nobody has registered a view yet.

Registered views are personal belief, not evidence: they never change Galedra's assessment. Affiliations are self-declared and shown only for groups of 5 or more.

Checked as part of

Statements this claim was broken out of. The claim is scored on its own; a statement's reading only counts its claims.

“In the AMP trials, prophylactic VRC01 selected de novo HIV escape mutations in 8 of 26 treated participants but none of 21 placebo participants; several...” · 1 claim · 29 September 2026
“In the AMP trials, prophylactic VRC01 selected de novo HIV escape mutations in 8 of 26 treated participants but none of 21 placebo participants; several...” · 1 claim · 29 September 2026
“In the AMP trials, prophylactic VRC01 selected de novo HIV escape mutations in 8 of 26 treated participants but none of 21 placebo participants; several...” · 1 claim · 29 September 2026

Evidence for

The AMP sequence analysis found escape in 8/26 VRC01 recipients versus 0/21 placebo participants, with cross-resistance but resilience of N6 and 1–18.

From Prophylactic treatment with broadly neutralizing antibody VRC01 selects for escape mutants after infection in Antibody-Mediated Prevention trials Read 2026-09-29 Relevance DIRECT Steps 0 Counted
The passage directly reports the treated and placebo counts, cross-resistance, and retained activity of N6 and 1–18.

From Prophylactic treatment with broadly neutralizing antibody VRC01 selects for escape mutants after infection in Antibody-Mediated Prevention trials Read 2026-09-29 Relevance DIRECT Steps 0 Counted
The primary AMP-trial analysis reports VRC01-associated escape in treated participants, low global frequencies, cross-resistance for some antibodies, and retained activity for N6 and 1–18.

From Prophylactic treatment with broadly neutralizing antibody VRC01 selects for escape mutants after infection in Antibody-Mediated Prevention trials Read 2026-09-29 Relevance DIRECT Steps 0 Counted

Independent primary clinical-trial sequence analysis.
The primary AMP-trial analysis reports de novo escape mutations in 8 of 26 VRC01-treated participants and none in 21 placebo participants.

From Prophylactic treatment with broadly neutralizing antibody VRC01 selects for escape mutants after infection in Antibody-Mediated Prevention trials Read 2026-09-29 Relevance DIRECT Steps 0 Counted

Short exact abstract passage from the primary analysis.
The AMP analysis found de novo VRC01 escape in 8 of 26 treated participants versus none of 21 placebo participants, with cross-resistance while N6 and 1–18 largely retained activity.

From Prophylactic treatment with broadly neutralizing antibody VRC01 selects for escape mutants after infection in Antibody-Mediated Prevention trials Read 2026-09-29 Relevance DIRECT Steps 0 Counted

Evidence against

None.

Qualifications

None.

Suppressed as dependent

Evidence	Group	Kept instead
740fc832		52d299f1
624a3b01		cb36780f

Inferences

Concluded from

None.

Used as a premise in

None.

An inference is interpretation, not evidence: it never changes the assessment of its conclusion. Each premise is a claim with its own evidence.

Threads

None. Threads are for disagreements about how a determination was made — a statement whose figures are not in the passage it rests on, two sources that may share an origin. Something about the world belongs in the evidence above.

Claim edges

None. Edges are stored and displayed; v0.1 does not propagate probability across them.

Review checklist

Review checks: 1 of 4

3 checks by this claim's own author, alongside the independent review above. 1 OPPOSING EVIDENCE SEARCH · 1 QUALIFIER CHECK · 1 EVIDENCE VERIFICATION. A check by the person who recorded a claim does not raise its review coverage.

Check	Done	By
qualifiers reviewed	no
opposing search done	no
independence reviewed	no
primary source reviewed	yes	1bbfc723, 52d299f1, 5ab26286, b5b98ed8, cb36780f

Summary

Insufficient evidence. No counted evidence bears on this claim yet. coverage:8d343107-f7d5-8b80-8b39-5a5bfc4c6343

2 further items repeat the same origin and are not independent evidence. 740fc832624a3b01

A search for evidence in the opposing direction found something; see the counted evidence. 0af95678

Review checks: 1 of 4. coverage:8d343107-f7d5-8b80-8b39-5a5bfc4c6343

Generated by stub-v0.1; every sentence cites graph ids.

Contribution history

seq	event	detail
18812	APPENDED
18813	ACCEPT	AUTOMATIC_AFTER_VALIDATION
18818	LINK_EVIDENCE	by 1efd24fe (accepted)
18852	TASK_RESULT	by 1efd24fe (accepted)
20144	LINK_EVIDENCE	by 1efd24fe (accepted)
20150	LINK_EVIDENCE	by 1efd24fe (accepted)
24307	TASK_RESULT	by 1efd24fe (accepted)

Score trace

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