Claim

Model ledger-default@0.1.0 ledger-strict@0.1.0 ledger-default@0.2.0 ledger-strict@0.2.0 ledger-default@0.3.0 (default) ledger-strict@0.3.0 Snapshot seq

Topics

Vaccines · 1efd24fe Biology · 1efd24fe

Assessment

Why?

Suppressed as dependent: The passage directly reports the treated and placebo counts, cross-resistance, and retained activity of N6 and 1–18.; The AMP analysis found de novo VRC01 escape in 8 of 26 treated participants versus none of 21 placebo participants, with cross-resistance while N6 and 1–18 largely retained activity.

Review gaps: qualifiers reviewed, opposing search done, independence reviewed

What would most change this: One independent, direct measurement that supports this claim would move it from Insufficient evidence to Supported.

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Checked as part of

Statements this claim was broken out of. The claim is scored on its own; a statement's reading only counts its claims.

• “In the AMP trials, prophylactic VRC01 selected de novo HIV escape mutations in 8 of 26 treated participants but none of 21 placebo participants; several...” · 1 claim · 29 September 2026
• “In the AMP trials, prophylactic VRC01 selected de novo HIV escape mutations in 8 of 26 treated participants but none of 21 placebo participants; several...” · 1 claim · 29 September 2026
• “In the AMP trials, prophylactic VRC01 selected de novo HIV escape mutations in 8 of 26 treated participants but none of 21 placebo participants; several...” · 1 claim · 29 September 2026

Evidence for

• The AMP sequence analysis found escape in 8/26 VRC01 recipients versus 0/21 placebo participants, with cross-resistance but resilience of N6 and 1–18.

  From Prophylactic treatment with broadly neutralizing antibody VRC01 selects for escape mutants after infection in Antibody-Mediated Prevention trials Read 2026-09-29 Relevance DIRECT Steps 0 Counted

• The passage directly reports the treated and placebo counts, cross-resistance, and retained activity of N6 and 1–18.

  From Prophylactic treatment with broadly neutralizing antibody VRC01 selects for escape mutants after infection in Antibody-Mediated Prevention trials Read 2026-09-29 Relevance DIRECT Steps 0 Counted

• The primary AMP-trial analysis reports VRC01-associated escape in treated participants, low global frequencies, cross-resistance for some antibodies, and retained activity for N6 and 1–18.

  From Prophylactic treatment with broadly neutralizing antibody VRC01 selects for escape mutants after infection in Antibody-Mediated Prevention trials Read 2026-09-29 Relevance DIRECT Steps 0 Counted

  Independent primary clinical-trial sequence analysis.

• The primary AMP-trial analysis reports de novo escape mutations in 8 of 26 VRC01-treated participants and none in 21 placebo participants.

  From Prophylactic treatment with broadly neutralizing antibody VRC01 selects for escape mutants after infection in Antibody-Mediated Prevention trials Read 2026-09-29 Relevance DIRECT Steps 0 Counted

  Short exact abstract passage from the primary analysis.

• The AMP analysis found de novo VRC01 escape in 8 of 26 treated participants versus none of 21 placebo participants, with cross-resistance while N6 and 1–18 largely retained activity.

  From Prophylactic treatment with broadly neutralizing antibody VRC01 selects for escape mutants after infection in Antibody-Mediated Prevention trials Read 2026-09-29 Relevance DIRECT Steps 0 Counted

Evidence against

None.

Qualifications

None.

Suppressed as dependent

Evidence	Group	Kept instead
740fc832		52d299f1
624a3b01		cb36780f

Inferences

Concluded from

None.

Used as a premise in

None.

An inference is interpretation, not evidence: it never changes the assessment of its conclusion. Each premise is a claim with its own evidence.

Threads

None. Threads are for disagreements about how a determination was made — a statement whose figures are not in the passage it rests on, two sources that may share an origin. Something about the world belongs in the evidence above.

Claim edges

None. Edges are stored and displayed; v0.1 does not propagate probability across them.

Review checklist

Review checks: 1 of 4

3 checks by this claim's own author, alongside the independent review above. 1 OPPOSING EVIDENCE SEARCH · 1 QUALIFIER CHECK · 1 EVIDENCE VERIFICATION. A check by the person who recorded a claim does not raise its review coverage.

Check	Done	By
qualifiers reviewed	no
opposing search done	no
independence reviewed	no
primary source reviewed	yes	1bbfc723, 52d299f1, 5ab26286, b5b98ed8, cb36780f

Summary

Contribution history

seq	event	detail
18812	APPENDED
18813	ACCEPT	AUTOMATIC_AFTER_VALIDATION
18818	LINK_EVIDENCE	by 1efd24fe (accepted)
18852	TASK_RESULT	by 1efd24fe (accepted)
20144	LINK_EVIDENCE	by 1efd24fe (accepted)
20150	LINK_EVIDENCE	by 1efd24fe (accepted)
24307	TASK_RESULT	by 1efd24fe (accepted)