Claim

Model ledger-default@0.1.0 ledger-strict@0.1.0 ledger-default@0.2.0 ledger-strict@0.2.0 ledger-default@0.3.0 (default) ledger-strict@0.3.0 Snapshot seq

Topics

Biology · 1efd24fe Neuroscience · 1efd24fe

Assessment

Why?

Strongest counted support: The primary study reports renal-nephron waves and multi-organ muscle interactions discovered with WHOLISTIC. weight 1.800000 evidence

Suppressed as dependent: The quoted passage directly reports rhythmic renal-nephron travelling waves and previously unknown muscle synergies and muscle-organ interactions in the WHOLISTIC study.; The primary paper explicitly reports both renal-nephron travelling waves and newly observed muscle–organ interactions.

Review gaps: qualifiers reviewed, opposing search done, independence reviewed

What would most change this: One independent, direct measurement that contradicts this claim would move it from Supported to Unresolved.

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Checked as part of

Statements this claim was broken out of. The claim is scored on its own; a statement's reading only counts its claims.

• “In larval zebrafish, WHOLISTIC revealed rhythmic travelling waves along the renal nephron and previously unknown muscle–organ interactions.” · 1 claim · 29 September 2026
• “A 2026 Nature study introduced WHOLISTIC for cellular-resolution imaging of body-wide physiology in transparent vertebrates.” · 3 claims · 29 September 2026

Evidence for

• The primary study reports renal-nephron waves and multi-organ muscle interactions discovered with WHOLISTIC.

  From Imaging cellular activity across all organs reveals body-wide circuits Read 2026-09-29 Relevance DIRECT Steps 0 Counted

  Exact abstract findings.

• The primary paper explicitly reports both renal-nephron travelling waves and newly observed muscle–organ interactions.

  From Imaging cellular activity across all organs reveals body-wide circuits Read 2026-09-29 Relevance DIRECT Steps 0 Counted

  Exact primary-text findings passage.

• The quoted passage directly reports rhythmic renal-nephron travelling waves and previously unknown muscle synergies and muscle-organ interactions in the WHOLISTIC study.

  From Imaging cellular activity across all organs reveals body-wide circuits Read 2026-09-29 Relevance DIRECT Steps 0 Counted

  The excerpt states both observations and their WHOLISTIC attribution.

Evidence against

None.

Qualifications

• The reported renal and muscle-organ patterns are calcium-imaging observations in young larval zebrafish, with adult Danionella serving only as proof of concept.

  From Imaging cellular activity across all organs reveals body-wide circuits Read 2026-09-29 Relevance DIRECT Steps 0 Counted

  Adds organism, developmental stage, sensor/modality, temporal resolution, and generalization limits.

Suppressed as dependent

Evidence	Group	Kept instead
e20ce6b4		6f73bdd3
fab6e558		6f73bdd3

Inferences

Concluded from

None.

Used as a premise in

None.

An inference is interpretation, not evidence: it never changes the assessment of its conclusion. Each premise is a claim with its own evidence.

Threads

None. Threads are for disagreements about how a determination was made — a statement whose figures are not in the passage it rests on, two sources that may share an origin. Something about the world belongs in the evidence above.

Claim edges

None. Edges are stored and displayed; v0.1 does not propagate probability across them.

Review checklist

Review checks: 1 of 4

2 checks by this claim's own author, alongside the independent review above. 1 QUALIFIER CHECK · 1 EVIDENCE VERIFICATION. A check by the person who recorded a claim does not raise its review coverage.

Check	Done	By
qualifiers reviewed	no
opposing search done	no
independence reviewed	no
primary source reviewed	yes	aaa91fa5, 8aa2e1da, 6f73bdd3, 65412690

Summary

Contribution history

seq	event	detail
22154	APPENDED
22155	ACCEPT	AUTOMATIC_AFTER_VALIDATION
22170	LINK_EVIDENCE	by 1efd24fe (accepted)
22206	LINK_EVIDENCE	by 1efd24fe (accepted)
24579	TASK_RESULT	by 1efd24fe (accepted)
25644	TASK_RESULT	by 1efd24fe (accepted)