Claim

In the study’s eight-center external CT test cohorts, EAGLE achieved 98.5% specificity, 90.0% cancer sensitivity and 52.5% precancerous-lesion sensitivity.

Type QUANTITATIVE · truth-evaluable: yes · status at snapshot: ACTIVE · created seq 20816

a conjunction joins clauses that may be separately evaluablea comma-separated series may list several propositions

Referenced 145 times: checked 2, looked up by assistants 0, viewed 97, shared 46. A count of attention, not evidence.

Topics

Medicine · 1efd24fe AI · 1efd24fe

Assessment

Supported

Score: 0.9781 under ledger-default@0.3.0 at snapshot 27745

2 of 4 review checks done · 1 counted · 1 by the author only

2 independent evidence lineages · review checks 1 of 4 · stability HIGH

Main unresolved issue: 6 counted evidence items have no independence review; repeats of one origin may be counted as several coverage:c57c9459-b73a-8122-8d93-5664d226efa5

Not yet independently audited.Evidence reviewed so far supports this claim, but only 1 of 4 review checks has been done.A quoted passage from nature.com was not found on the page when Galedra fetched it.

Why?

Strongest counted support: The primary study reports external-cohort specificity and sensitivity results. weight 2.000000 evidence

Suppressed as dependent: The excerpt directly reports eight-center external cohorts with 98.5% specificity, 90.0% cancer sensitivity, and 52.5% precancerous-lesion sensitivity.

Review gaps: qualifiers reviewed, opposing search done, independence reviewed

What would most change this: One independent, direct measurement that contradicts this claim would move it from Supported to Supported.

Hide calculation

0.9781 under ledger-default@0.3.0 at snapshot 27745 · state Supported · Review checks: 1 of 4 · stability HIGH · 6 sources, 2 independent lineages

Model ledger-default@0.3.0 (the default model, not the answer) · snapshot 27745 · trace sha256:984dc4f40ea2105aa6be6e4453734ebf3fd57f669ca68f8161ba79d41fe4567e

Last changed at entry seq 26054; nothing logged since has borne on this claim.

How the number was reached

Each counted link is weighed by multiplying the factors the model declares; a factor it does not declare is not shown. Every factor name below links to what that number means.

Link	Working	Weight	Counted as
14900311 support	relevance DIRECT 2.0 × observation DIRECT_TEXT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	1.800000	1.800000
5211f754 qualify	relevance DIRECT 2.0 × observation DIRECT_TEXT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	1.800000	0.000000 (non directional)
6bb9ebe0 support	relevance DIRECT 2.0 × observation MEASUREMENT 1.0 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	2.000000	0.000000 (dependent strongest only, kept 97e33cab)
09b3e519 qualify	relevance DIRECT 2.0 × observation DIRECT_TEXT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	1.800000	0.000000 (non directional)
c31ced69 qualify	relevance DIRECT 2.0 × observation DIRECT_TEXT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	1.800000	0.000000 (non directional)
97e33cab support	relevance DIRECT 2.0 × observation MEASUREMENT 1.0 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	2.000000	2.000000

prior 0.50 → log-odds 0.000000 + 3.800000 (the counted weights) = 3.800000 → probability 0.9781

Under neighbouring settings of the same model: 0.9346 to 0.9929, a spread of 0.0583.

Half-even rounding, six places for weights and four for the probability. The same inputs under the same model reproduce this exactly; that is what the trace hash above is for. How a score is worked out explains every factor, why it is there, and what the model sets it to.

Your view

Registered views

Nobody has registered a view yet.

Registered views are personal belief, not evidence: they never change Galedra's assessment. Affiliations are self-declared and shown only for groups of 5 or more.

Checked as part of

Statements this claim was broken out of. The claim is scored on its own; a statement's reading only counts its claims.

“In the study’s eight-center external CT test cohorts, EAGLE achieved 98.5% specificity, 90.0% cancer sensitivity and 52.5% precancerous-lesion sensitivity.” · 1 claim · 29 September 2026
“A primary Nature Medicine study developed and evaluated EAGLE, an AI model for detecting esophageal malignancy and precancerous lesions from noncontrast...” · 3 claims · 29 September 2026

Evidence for

The primary study reports external-cohort specificity and sensitivity results.

From Large-scale esophageal cancer screening through noncontrast computed tomography and artificial intelligence Read 2026-09-29 Relevance DIRECT Steps 0 Counted

Primary external validation result.
The primary study directly reports the external-cohort specificity and sensitivity results.

From Large-scale esophageal cancer screening through noncontrast computed tomography and artificial intelligence Read 2026-09-29 Relevance DIRECT Steps 0 Counted

Additional direct evidence for the newly created validation claim.
The excerpt directly reports eight-center external cohorts with 98.5% specificity, 90.0% cancer sensitivity, and 52.5% precancerous-lesion sensitivity.

From Large-scale esophageal cancer screening through noncontrast computed tomography and artificial intelligence Read 2026-09-29 Relevance DIRECT Steps 0 Counted

Evidence against

None.

Qualifications

The metrics apply to eight-center external opportunistic screening cohorts totaling 11,466 existing noncontrast-CT scans.

From Large-scale esophageal cancer screening through noncontrast computed tomography and artificial intelligence Read 2026-09-29 Relevance DIRECT Steps 0 Counted
The 52.5% precancerous-lesion result refers to HGIN and the 90.0% cancer result to EC, with multicenter external-test estimates and confidence intervals.

From Large-scale esophageal cancer screening through noncontrast computed tomography and artificial intelligence Read 2026-09-29 Relevance DIRECT Steps 0 Counted
Specificity and sensitivity depend on the selected decision threshold, calibrated near 99% specificity for opportunistic screening.

From Large-scale esophageal cancer screening through noncontrast computed tomography and artificial intelligence Read 2026-09-29 Relevance DIRECT Steps 0 Counted

Suppressed as dependent

Evidence	Group	Kept instead
2b8575eb		97e33cab

Inferences

Concluded from

None.

Used as a premise in

None.

An inference is interpretation, not evidence: it never changes the assessment of its conclusion. Each premise is a claim with its own evidence.

Threads

None. Threads are for disagreements about how a determination was made — a statement whose figures are not in the passage it rests on, two sources that may share an origin. Something about the world belongs in the evidence above.

Claim edges

None. Edges are stored and displayed; v0.1 does not propagate probability across them.

Review checklist

Review checks: 1 of 4

2 checks by this claim's own author, alongside the independent review above. 1 QUALIFIER CHECK · 1 EVIDENCE VERIFICATION. A check by the person who recorded a claim does not raise its review coverage.

Check	Done	By
qualifiers reviewed	no
opposing search done	no
independence reviewed	no
primary source reviewed	yes	14900311, 5211f754, 6bb9ebe0, 09b3e519, c31ced69, 97e33cab

Summary

Supported. The main support is: The primary study directly reports the external-cohort specificity and sensitivity results. 7e24a08e

1 further item repeats the same origin and is not independent evidence. 2b8575eb

Qualifier: The 52.5% precancerous-lesion result refers to HGIN and the 90.0% cancer result to EC, with multicenter external-test estimates and confidence intervals. 436c4bf4

Qualifier: The metrics apply to eight-center external opportunistic screening cohorts totaling 11,466 existing noncontrast-CT scans. 6d507348

Qualifier: Specificity and sensitivity depend on the selected decision threshold, calibrated near 99% specificity for opportunistic screening. baae8ecf

Review checks: 1 of 4. coverage:c57c9459-b73a-8122-8d93-5664d226efa5

Generated by stub-v0.1; every sentence cites graph ids.

Contribution history

seq	event	detail
20816	APPENDED
20817	ACCEPT	AUTOMATIC_AFTER_VALIDATION
20832	LINK_EVIDENCE	by 1efd24fe (accepted)
20921	LINK_EVIDENCE	by 1efd24fe (accepted)
24827	TASK_RESULT	by 1efd24fe (accepted)
26053	TASK_RESULT	by 1efd24fe (accepted)

Score trace

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  "contested": false,
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