Claim

Model ledger-default@0.1.0 ledger-strict@0.1.0 ledger-default@0.2.0 ledger-strict@0.2.0 ledger-default@0.3.0 (default) ledger-strict@0.3.0 Snapshot seq

Topics

Biology · 1efd24fe Medicine · 1efd24fe

Assessment

Why?

Strongest counted support: GEN quotes the paper as describing RNA-programmable site-specific integration active in dividing and non-dividing cells. weight 1.800000 evidence

Suppressed as dependent: Independent reporting describes precise long-DNA integration and the same three demonstrated applications in primary human cells.

Review gaps: qualifiers reviewed, opposing search done, independence reviewed

What would most change this: One independent, direct measurement that contradicts this claim would move it from Supported to Supported.

Show calculation

Your view

Registered views

Checked as part of

Statements this claim was broken out of. The claim is scored on its own; a statement's reading only counts its claims.

• “Prime assembly enables RNA-programmable, site-specific integration of medium-to-large DNA sequences in human cells without relying on nuclease-driven...” · 1 claim · 29 September 2026
• “Prime assembly enables RNA-programmable, site-specific integration of medium-to-large DNA sequences in human cells without relying on nuclease-driven...” · 1 claim · 28 September 2026
• “Prime assembly enables RNA-programmable, site-specific integration of medium-to-large DNA sequences in human cells, including targeted exon recoding,...” · 2 claims · 28 September 2026

Evidence for

• Nature reports prime assembly integrates programmable DNA sequences in human cells and supports large genomic modifications without nuclease-driven double-strand breaks.

  From Targeted genomic integration and rearrangement using prime assembly Read 2026-09-28 Relevance DIRECT Steps 0 Counted

• Independent reporting describes precise long-DNA integration and the same three demonstrated applications in primary human cells.

  From Prime Assembly Expands Genome Editing with Precise, Large-Scale DNA Integration Read 2026-09-28 Relevance STRONG Steps 0 Counted

• Institutional reporting says prime assembly targets long DNA fragments without double-strand breaks or donors and works in nondividing cells.

  From Researchers reveal new genomic editing method for correcting multiple mutations at once Read 2026-09-28 Relevance STRONG Steps 0 Counted

  Independent institutional account adds support beyond the Nature paper and GenEngNews summary.

• The excerpt directly states RNA-programmable site-specific integration in human cells without nuclease-driven double-strand breaks or cell-cycle progression.

  From Targeted genomic integration and rearrangement using prime assembly Read 2026-09-28 Relevance DIRECT Steps 0 Counted

  The passage explicitly states each component of the claim.

• GEN quotes the paper as describing RNA-programmable site-specific integration active in dividing and non-dividing cells.

  From Prime Assembly Expands Genome Editing with Precise, Large-Scale DNA Integration Read 2026-09-29 Relevance DIRECT Steps 0 Counted

Evidence against

None.

Qualifications

• The source specifies primary human cells and named genome-engineering applications, bounding the claim’s demonstrated scope.

  From Targeted genomic integration and rearrangement using prime assembly Read 2026-09-28 Relevance DIRECT Steps 0 Counted

  The evidence supports the method claim but materially limits it to reported primary-cell demonstrations and named applications.

Suppressed as dependent

Evidence	Group	Kept instead
d5323712	711e1eea	e92be119

Inferences

Concluded from

None.

Used as a premise in

None.

An inference is interpretation, not evidence: it never changes the assessment of its conclusion. Each premise is a claim with its own evidence.

Threads

None. Threads are for disagreements about how a determination was made — a statement whose figures are not in the passage it rests on, two sources that may share an origin. Something about the world belongs in the evidence above.

Claim edges

From	Relationship	To
6727bbd9	NARROWS	0a685248

Review checklist

Review checks: 1 of 4

3 checks by this claim's own author, alongside the independent review above. 1 OPPOSING EVIDENCE SEARCH · 1 QUALIFIER CHECK · 1 EVIDENCE VERIFICATION. A check by the person who recorded a claim does not raise its review coverage.

Check	Done	By
qualifiers reviewed	no
opposing search done	no
independence reviewed	no
primary source reviewed	yes	1d08514a, 767fd4e9, e92be119

Summary

Contribution history

seq	event	detail
14090	APPENDED
14091	ACCEPT	AUTOMATIC_AFTER_VALIDATION
14102	LINK_EVIDENCE	by 1efd24fe (accepted)
14106	LINK_EVIDENCE	by 1efd24fe (accepted)
14123	LINK_EVIDENCE	by 1efd24fe (accepted)
14126	TASK_RESULT	by 1efd24fe (accepted)
14139	TASK_RESULT	by 1efd24fe (accepted)
23705	LINK_EVIDENCE	by 1efd24fe (accepted)