Claim

In the study, inflammasome priming upregulated Gsdmd-Tmem106a and its protein localized to the plasma membrane.

Type OBSERVATIONAL · truth-evaluable: yes · status at snapshot: ACTIVE · created seq 21590

a conjunction joins clauses that may be separately evaluable

Referenced 112 times: checked 2, looked up by assistants 0, viewed 72, shared 38. A count of attention, not evidence.

Topics

Biology · 1efd24fe Health · 1efd24fe

Assessment

Supported

Score: 0.8808 under ledger-default@0.3.0 at snapshot 27745

1 of 4 review checks done · 1 counted

1 independent evidence lineage · review checks 1 of 4 · stability MEDIUM

Main unresolved issue: 3 counted evidence items have no independence review; repeats of one origin may be counted as several coverage:d71f8d71-568d-8e6d-a9a4-565e2ad9e89e

Not yet independently audited.Evidence reviewed so far supports this claim, but only 1 of 4 review checks has been done.Every quoted passage was confirmed on the page when Galedra fetched it.

Why?

Strongest counted support: The primary study reports inflammation-linked expression and plasma-membrane localization of the fusion protein. weight 2.000000 evidence

Suppressed as dependent: The passage directly reports inflammasome priming upregulating Gsdmd-Tmem106a and the resulting protein localizing to the plasma membrane.; The primary Nature study directly reports inflammasome-linked upregulation and plasma-membrane localization.

Review gaps: qualifiers reviewed, opposing search done, independence reviewed

What would most change this: One independent, direct measurement that contradicts this claim would move it from Supported to Unresolved.

Hide calculation

0.8808 under ledger-default@0.3.0 at snapshot 27745 · state Supported · Review checks: 1 of 4 · stability MEDIUM · 3 sources, 1 independent lineage

Model ledger-default@0.3.0 (the default model, not the answer) · snapshot 27745 · trace sha256:4dee006519c2dc6a1fa3339a8292ce6164f8aa495d1992eed0f8113c2def4c0b

Last changed at entry seq 24855; nothing logged since has borne on this claim.

How the number was reached

Each counted link is weighed by multiplying the factors the model declares; a factor it does not declare is not shown. Every factor name below links to what that number means.

Link	Working	Weight	Counted as
a6b9ea63 support	relevance DIRECT 2.0 × observation MEASUREMENT 1.0 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	2.000000	2.000000
f2fbd5a5 support	relevance DIRECT 2.0 × observation DIRECT_TEXT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	1.800000	0.000000 (dependent strongest only, kept a6b9ea63)
5a25a4d7 support	relevance DIRECT 2.0 × observation DIRECT_TEXT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	1.800000	0.000000 (dependent strongest only, kept a6b9ea63)

prior 0.50 → log-odds 0.000000 + 2.000000 (the counted weights) = 2.000000 → probability 0.8808

Under neighbouring settings of the same model: 0.8022 to 0.9309, a spread of 0.1287.

Half-even rounding, six places for weights and four for the probability. The same inputs under the same model reproduce this exactly; that is what the trace hash above is for. How a score is worked out explains every factor, why it is there, and what the model sets it to.

Your view

Registered views

Nobody has registered a view yet.

Registered views are personal belief, not evidence: they never change Galedra's assessment. Affiliations are self-declared and shown only for groups of 5 or more.

Checked as part of

Statements this claim was broken out of. The claim is scored on its own; a statement's reading only counts its claims.

“In the study, inflammasome priming upregulated Gsdmd-Tmem106a and its protein localized to the plasma membrane.” · 1 claim · 29 September 2026
“A primary Nature study investigated regulated chimeric mRNAs and their protein functions during mammalian inflammation and immunity.” · 3 claims · 29 September 2026

Evidence for

The primary study reports inflammation-linked expression and plasma-membrane localization of the fusion protein.

From Functional chimeric mRNAs encode proteins in mammalian immunity Read 2026-09-29 Relevance DIRECT Steps 0 Counted

Primary expression and localization result.
The primary Nature study directly reports inflammasome-linked upregulation and plasma-membrane localization.

From Functional chimeric mRNAs encode proteins in mammalian immunity Read 2026-09-29 Relevance DIRECT Steps 0 Counted

Independent attachment of the exact primary-study result.
The passage directly reports inflammasome priming upregulating Gsdmd-Tmem106a and the resulting protein localizing to the plasma membrane.

From Functional chimeric mRNAs encode proteins in mammalian immunity Read 2026-09-29 Relevance DIRECT Steps 0 Counted

Expression response and localization match exactly.

Evidence against

None.

Qualifications

None.

Suppressed as dependent

Evidence	Group	Kept instead
f6ea4957		a6b9ea63
4eefdcbe		a6b9ea63

Inferences

Concluded from

None.

Used as a premise in

None.

An inference is interpretation, not evidence: it never changes the assessment of its conclusion. Each premise is a claim with its own evidence.

Threads

None. Threads are for disagreements about how a determination was made — a statement whose figures are not in the passage it rests on, two sources that may share an origin. Something about the world belongs in the evidence above.

Claim edges

None. Edges are stored and displayed; v0.1 does not propagate probability across them.

Review checklist

Review checks: 1 of 4

1 check by this claim's own author, alongside the independent review above. 1 EVIDENCE VERIFICATION. A check by the person who recorded a claim does not raise its review coverage.

Check	Done	By
qualifiers reviewed	no
opposing search done	no
independence reviewed	no
primary source reviewed	yes	a6b9ea63, f2fbd5a5, 5a25a4d7

Summary

Supported. The main support is: The primary study reports inflammation-linked expression and plasma-membrane localization of the fusion protein. b1942f88

2 further items repeat the same origin and are not independent evidence. f6ea49574eefdcbe

Review checks: 1 of 4. coverage:d71f8d71-568d-8e6d-a9a4-565e2ad9e89e

Generated by stub-v0.1; every sentence cites graph ids.

Contribution history

seq	event	detail
21590	APPENDED
21591	ACCEPT	AUTOMATIC_AFTER_VALIDATION
21606	LINK_EVIDENCE	by 1efd24fe (accepted)
21618	LINK_EVIDENCE	by 1efd24fe (accepted)
24854	TASK_RESULT	by 1efd24fe (accepted)

Score trace

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  "claim": "d71f8d71-568d-8e6d-a9a4-565e2ad9e89e",
  "links": [
    {
      "link": "ba8586cf-0e69-8e19-8ea6-6c52a6b9ea63",
      "group": null,
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "1f9dbedc-da34-8d0a-b0ad-895bb1942f88",
      "direction": "SUPPORT",
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      "relevance": "DIRECT",
      "extraction": "UNVERIFIED",
      "provenance": "INDEPENDENT",
      "observation": "MEASUREMENT",
      "source_type": "PRIMARY_TEXT",
      "authenticity": "UNVERIFIED",
      "audit_confirmed": false,
      "effective_weight": "2.000000",
      "interpretive_steps": 0
    },
    {
      "kept": "ba8586cf-0e69-8e19-8ea6-6c52a6b9ea63",
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      "group": null,
      "reason": "dependent_strongest_only",
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "3e66169c-5951-8ab3-b1ee-fdbaf6ea4957",
      "direction": "SUPPORT",
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      "relevance": "DIRECT",
      "extraction": "UNVERIFIED",
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      "authenticity": "UNVERIFIED",
      "audit_confirmed": false,
      "effective_weight": "0.000000",
      "interpretive_steps": 0
    },
    {
      "kept": "ba8586cf-0e69-8e19-8ea6-6c52a6b9ea63",
      "link": "eaef6a15-7b0e-8a5a-8369-a4995a25a4d7",
      "group": null,
      "reason": "dependent_strongest_only",
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "3d3813b4-6365-8666-a447-d5cb4eefdcbe",
      "direction": "SUPPORT",
      "magnitude": "1.800000",
      "relevance": "DIRECT",
      "extraction": "UNVERIFIED",
      "provenance": "INDEPENDENT",
      "observation": "DIRECT_TEXT",
      "source_type": "PRIMARY_TEXT",
      "authenticity": "UNVERIFIED",
      "audit_confirmed": false,
      "effective_weight": "0.000000",
      "interpretive_steps": 0
    }
  ],
  "model": "ledger-default@0.3.0",
  "prior": "0.50",
  "variants": {
    "spread": "0.1287",
    "permissive": "0.9309",
    "conservative": "0.8022"
  },
  "code_hash": "sha256:c61a6fdf35a754a0d7e958df149036a083c0eaeb7d2d2e52704ec32b0c36def7",
  "contested": false,
  "stability": "MEDIUM",
  "claim_type": "OBSERVATIONAL",
  "config_hash": "sha256:86768038080b8ab5233f1e4b7aba10af05b5bb44caa432095150b90e81209809",
  "probability": "0.8808",
  "provisional": true,
  "evidence_sum": "2.000000",
  "snapshot_seq": 24855,
  "prior_log_odds": "0.000000",
  "support_groups": 1,
  "model_dependent": false,
  "review_coverage": "0.25",
  "truth_evaluable": true,
  "assessment_state": "SUPPORTED",
  "review_checklist": {
    "qualifiers_reviewed": {
      "by": [],
      "ok": false
    },
    "opposing_search_done": {
      "by": [],
      "ok": false
    },
    "independence_reviewed": {
      "by": [],
      "ok": false
    },
    "primary_source_reviewed": {
      "by": [
        "ba8586cf-0e69-8e19-8ea6-6c52a6b9ea63",
        "e30cd130-b1b9-8dfe-a167-a5e0f2fbd5a5",
        "eaef6a15-7b0e-8a5a-8369-a4995a25a4d7"
      ],
      "ok": true
    }
  },
  "contradict_groups": 0,
  "rounding_boundary": false,
  "posterior_log_odds": "2.000000",
  "not_applicable_reason": null,
  "independence_unreviewed": 3
}