Claim

Model ledger-default@0.1.0 ledger-strict@0.1.0 ledger-default@0.2.0 ledger-strict@0.2.0 ledger-default@0.3.0 (default) ledger-strict@0.3.0 Snapshot seq

Topics

Neuroscience · 1efd24fe Health · 1efd24fe

Assessment

Why?

Strongest counted support: The primary atlas reports disease-linked cell-type-specific genes that bulk-tissue analyses did not detect. weight 1.800000 evidence

Suppressed as dependent: The quoted passage directly reports Alzheimer’s, schizophrenia, and other disorder-linked cell-type-specific genes not detectable in bulk tissue.

Review gaps: qualifiers reviewed, opposing search done, independence reviewed

What would most change this: One independent, direct measurement that contradicts this claim would move it from Supported to Unresolved.

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Checked as part of

Statements this claim was broken out of. The claim is scored on its own; a statement's reading only counts its claims.

• “A 2026 Nature Genetics study built a multi-ancestry single-nucleus atlas of human prefrontal-cortex genetic regulation and identified cell-type-specific...” · 2 claims · 29 September 2026

Evidence for

• The primary atlas reports disease-linked cell-type-specific genes that bulk-tissue analyses did not detect.

  From Single-nucleus atlas of cell-type specific genetic regulation in the human brain Read 2026-09-29 Relevance DIRECT Steps 0 Counted

  Primary colocalization result.

• The quoted passage directly reports Alzheimer’s, schizophrenia, and other disorder-linked cell-type-specific genes not detectable in bulk tissue.

  From Single-nucleus atlas of cell-type specific genetic regulation in the human brain Read 2026-09-29 Relevance DIRECT Steps 0 Counted

  The excerpt explicitly states the disease examples and bulk-tissue comparison.

Evidence against

None.

Qualifications

None.

Suppressed as dependent

Evidence	Group	Kept instead
4bb96b13		df2c60fe

Inferences

Concluded from

None.

Used as a premise in

None.

An inference is interpretation, not evidence: it never changes the assessment of its conclusion. Each premise is a claim with its own evidence.

Threads

None. Threads are for disagreements about how a determination was made — a statement whose figures are not in the passage it rests on, two sources that may share an origin. Something about the world belongs in the evidence above.

Claim edges

None. Edges are stored and displayed; v0.1 does not propagate probability across them.

Review checklist

Review checks: 1 of 4

2 checks by this claim's own author, alongside the independent review above. 1 QUALIFIER CHECK · 1 EVIDENCE VERIFICATION. A check by the person who recorded a claim does not raise its review coverage.

Check	Done	By
qualifiers reviewed	no
opposing search done	no
independence reviewed	no
primary source reviewed	yes	2e46cd4c, df2c60fe

Summary

Contribution history

seq	event	detail
18650	APPENDED
18651	ACCEPT	AUTOMATIC_AFTER_VALIDATION
18660	LINK_EVIDENCE	by 1efd24fe (accepted)
24471	TASK_RESULT	by 1efd24fe (accepted)

Score trace

{
  "claim": "f59900da-2f14-85c6-8b0b-209edb7450a8",
  "links": [
    {
      "kept": "dd125d70-3feb-8653-a6cf-097edf2c60fe",
      "link": "6836beab-ee7a-80cb-87b7-9a7c2e46cd4c",
      "group": null,
      "reason": "dependent_strongest_only",
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "f54ad545-0939-8a41-8583-95424bb96b13",
      "direction": "SUPPORT",
      "magnitude": "1.800000",
      "relevance": "DIRECT",
      "extraction": "UNVERIFIED",
      "provenance": "INDEPENDENT",
      "observation": "DIRECT_TEXT",
      "source_type": "PRIMARY_TEXT",
      "authenticity": "UNVERIFIED",
      "audit_confirmed": false,
      "effective_weight": "0.000000",
      "interpretive_steps": 0
    },
    {
      "link": "dd125d70-3feb-8653-a6cf-097edf2c60fe",
      "group": null,
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "25facbc4-a77e-8f91-a6bc-e407f162a51b",
      "direction": "SUPPORT",
      "magnitude": "1.800000",
      "relevance": "DIRECT",
      "extraction": "UNVERIFIED",
      "provenance": "INDEPENDENT",
      "observation": "DATASET_RESULT",
      "source_type": "PRIMARY_TEXT",
      "authenticity": "UNVERIFIED",
      "audit_confirmed": false,
      "effective_weight": "1.800000",
      "interpretive_steps": 0
    }
  ],
  "model": "ledger-default@0.3.0",
  "prior": "0.50",
  "variants": {
    "spread": "0.1331",
    "permissive": "0.9121",
    "conservative": "0.7790"
  },
  "code_hash": "sha256:c61a6fdf35a754a0d7e958df149036a083c0eaeb7d2d2e52704ec32b0c36def7",
  "contested": false,
  "stability": "MEDIUM",
  "claim_type": "OBSERVATIONAL",
  "config_hash": "sha256:86768038080b8ab5233f1e4b7aba10af05b5bb44caa432095150b90e81209809",
  "probability": "0.8581",
  "provisional": true,
  "evidence_sum": "1.800000",
  "snapshot_seq": 25458,
  "prior_log_odds": "0.000000",
  "support_groups": 1,
  "model_dependent": false,
  "review_coverage": "0.25",
  "truth_evaluable": true,
  "assessment_state": "SUPPORTED",
  "review_checklist": {
    "qualifiers_reviewed": {
      "by": [],
      "ok": false
    },
    "opposing_search_done": {
      "by": [],
      "ok": false
    },
    "independence_reviewed": {
      "by": [],
      "ok": false
    },
    "primary_source_reviewed": {
      "by": [
        "6836beab-ee7a-80cb-87b7-9a7c2e46cd4c",
        "dd125d70-3feb-8653-a6cf-097edf2c60fe"
      ],
      "ok": true
    }
  },
  "contradict_groups": 0,
  "rounding_boundary": false,
  "posterior_log_odds": "1.800000",
  "not_applicable_reason": null,
  "independence_unreviewed": 2
}