Claim

In Drosophila, genetic silencing of Lsp2 reduced early-adult ribosomal-protein abundance and translational activity while extending lifespan; restricting phenylalanine or tyrosine also reduced early-life Lsp2 and promoted longevity.

Type CAUSAL · truth-evaluable: yes · status at snapshot: ACTIVE · created seq 14843 · qualifiers {"population":"Drosophila under the study's laboratory dietary and genetic conditions; the claim concerns the reported interventions and does not establish a human anti-aging intervention."}

27 words; atomic claims are usually under 25a conjunction joins clauses that may be separately evaluable

Referenced 124 times: checked 2, looked up by assistants 1, viewed 79, shared 42. A count of attention, not evidence.

Topics

Nutrition · 1efd24fe Biology · 1efd24fe

Assessment

Supported

Score: 0.9601 under ledger-default@0.3.0 at snapshot 27745

3 of 4 review checks done · 1 counted · 2 by the author only

2 independent evidence lineages · review checks 1 of 4 · stability LOW

Main unresolved issue: 3 counted evidence items have no independence review; repeats of one origin may be counted as several coverage:fcd0c7fa-ff66-822f-9e42-bb5e265c876a

Not yet independently audited.This assessment depends heavily on modeling choices.Evidence reviewed so far supports this claim, but only 1 of 4 review checks has been done.Every quoted passage was confirmed on the page when Galedra fetched it.

Why?

Strongest counted support: The abstract reports Lsp2 silencing effects on translation, lifespan, and amino-acid restriction effects on Lsp2 and longevity. weight 2.000000 evidence

Suppressed as dependent: The excerpt directly reports Lsp2 silencing effects on ribosomal proteins, translation, lifespan, and amino-acid restriction effects.

Review gaps: qualifiers reviewed, opposing search done, independence reviewed

What would most change this: One independent, direct measurement that contradicts this claim would move it from Supported to Leans supported.

Hide calculation

0.9601 under ledger-default@0.3.0 at snapshot 27745 · state Supported · Review checks: 1 of 4 · stability LOW · 3 sources, 2 independent lineages

Model ledger-default@0.3.0 (the default model, not the answer) · snapshot 27745 · trace sha256:2c707b327a23dc2b6351910c3834fe277a9c671dfe57c445229304fa7afe10df

Last changed at entry seq 16645; nothing logged since has borne on this claim.

How the number was reached

Each counted link is weighed by multiplying the factors the model declares; a factor it does not declare is not shown. Every factor name below links to what that number means.

Link	Working	Weight	Counted as
2228390a support	relevance DIRECT 2.0 × observation MEASUREMENT 1.0 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	2.000000	2.000000
3ae6c1c8 support	relevance DIRECT 2.0 × observation MEASUREMENT 1.0 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	2.000000	0.000000 (dependent strongest only, kept 2228390a)
33607e74 support	relevance DIRECT 2.0 × observation DIRECT_TEXT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	1.800000	1.800000

prior 0.35 → log-odds -0.619039 + 3.800000 (the counted weights) = 3.180961 → probability 0.9601

Under neighbouring settings of the same model: 0.8850 to 0.9869, a spread of 0.1019.

Half-even rounding, six places for weights and four for the probability. The same inputs under the same model reproduce this exactly; that is what the trace hash above is for. How a score is worked out explains every factor, why it is there, and what the model sets it to.

Your view

Registered views

Nobody has registered a view yet.

Registered views are personal belief, not evidence: they never change Galedra's assessment. Affiliations are self-declared and shown only for groups of 5 or more.

Checked as part of

Statements this claim was broken out of. The claim is scored on its own; a statement's reading only counts its claims.

“In Drosophila, genetic silencing of Lsp2 reduced early-adult ribosomal-protein abundance and translational activity while extending lifespan; restricting...” · 1 claim · 29 September 2026
“A 2026 Nature study in Drosophila linked larval protein restriction to adult lifespan through Lsp2, a storage protein associated with translational capacity.” · 2 claims · 28 September 2026

Evidence for

The abstract reports Lsp2 silencing effects on translation, lifespan, and amino-acid restriction effects on Lsp2 and longevity.

From Lsp2 links early-life diet to adult translation and lifespan in Drosophila Read 2026-09-29 Relevance DIRECT Steps 0 Counted

The abstract directly reports the genetic and dietary interventions and their reported outcomes.
The excerpt directly reports Lsp2 silencing effects on ribosomal proteins, translation, lifespan, and amino-acid restriction effects.

From Lsp2 links early-life diet to adult translation and lifespan in Drosophila Read 2026-09-29 Relevance DIRECT Steps 0 Counted

The passage explicitly states each intervention and reported outcome.
The Nature study directly reports the Lsp2, early-adult translation, amino-acid restriction, and lifespan relationships summarized in this claim.

From Lsp2 links early-life diet to adult translation and lifespan in Drosophila Read 2026-09-29 Relevance DIRECT Steps 0 Counted

Primary research article abstract; independent line of evidence.

Evidence against

None.

Qualifications

None.

Suppressed as dependent

Evidence	Group	Kept instead
1285c38d		2228390a

Inferences

Concluded from

None.

Used as a premise in

None.

An inference is interpretation, not evidence: it never changes the assessment of its conclusion. Each premise is a claim with its own evidence.

Threads

None. Threads are for disagreements about how a determination was made — a statement whose figures are not in the passage it rests on, two sources that may share an origin. Something about the world belongs in the evidence above.

Claim edges

None. Edges are stored and displayed; v0.1 does not propagate probability across them.

Review checklist

Review checks: 1 of 4

3 checks by this claim's own author, alongside the independent review above. 1 OPPOSING EVIDENCE SEARCH · 1 QUALIFIER CHECK · 1 EVIDENCE VERIFICATION. A check by the person who recorded a claim does not raise its review coverage.

Check	Done	By
qualifiers reviewed	no
opposing search done	no
independence reviewed	no
primary source reviewed	yes	2228390a, 3ae6c1c8, 33607e74

Summary

Supported. The main support is: The abstract reports Lsp2 silencing effects on translation, lifespan, and amino-acid restriction effects on Lsp2 and longevity. db7d25e3

1 further item repeats the same origin and is not independent evidence. 1285c38d

A search for evidence in the opposing direction found none. 0c9d6ca2

Review checks: 1 of 4. coverage:fcd0c7fa-ff66-822f-9e42-bb5e265c876a

Generated by stub-v0.1; every sentence cites graph ids.

Contribution history

seq	event	detail
14843	APPENDED
14844	ACCEPT	AUTOMATIC_AFTER_VALIDATION
14853	LINK_EVIDENCE	by 1efd24fe (accepted)
14866	TASK_RESULT	by 1efd24fe (accepted)
16644	LINK_EVIDENCE	by 1efd24fe (accepted)

Score trace

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  "claim": "fcd0c7fa-ff66-822f-9e42-bb5e265c876a",
  "links": [
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      "link": "1e1fbfd6-7a5a-8987-a273-15b42228390a",
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      "evidence": "57ce27a1-60e3-8013-ba0f-9ac2db7d25e3",
      "direction": "SUPPORT",
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      "relevance": "DIRECT",
      "extraction": "UNVERIFIED",
      "provenance": "INDEPENDENT",
      "observation": "MEASUREMENT",
      "source_type": "PRIMARY_TEXT",
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      "audit_confirmed": false,
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      "interpretive_steps": 0
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      "kept": "1e1fbfd6-7a5a-8987-a273-15b42228390a",
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      "group": null,
      "reason": "dependent_strongest_only",
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      "relevance": "DIRECT",
      "extraction": "UNVERIFIED",
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      "audit_confirmed": false,
      "effective_weight": "0.000000",
      "interpretive_steps": 0
    },
    {
      "link": "9fc53ac2-428a-81d9-a2d4-5d8e33607e74",
      "group": null,
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "cfd1009f-8f6a-837b-b964-c806981bf6a1",
      "direction": "SUPPORT",
      "magnitude": "1.800000",
      "relevance": "DIRECT",
      "extraction": "UNVERIFIED",
      "provenance": "INDEPENDENT",
      "observation": "DIRECT_TEXT",
      "source_type": "PRIMARY_TEXT",
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      "audit_confirmed": false,
      "effective_weight": "1.800000",
      "interpretive_steps": 0
    }
  ],
  "model": "ledger-default@0.3.0",
  "prior": "0.35",
  "variants": {
    "spread": "0.1019",
    "permissive": "0.9869",
    "conservative": "0.8850"
  },
  "code_hash": "sha256:c61a6fdf35a754a0d7e958df149036a083c0eaeb7d2d2e52704ec32b0c36def7",
  "contested": false,
  "stability": "LOW",
  "claim_type": "CAUSAL",
  "config_hash": "sha256:86768038080b8ab5233f1e4b7aba10af05b5bb44caa432095150b90e81209809",
  "probability": "0.9601",
  "provisional": true,
  "evidence_sum": "3.800000",
  "snapshot_seq": 16645,
  "prior_log_odds": "-0.619039",
  "support_groups": 2,
  "model_dependent": true,
  "review_coverage": "0.25",
  "truth_evaluable": true,
  "assessment_state": "SUPPORTED",
  "review_checklist": {
    "qualifiers_reviewed": {
      "by": [],
      "ok": false
    },
    "opposing_search_done": {
      "by": [],
      "ok": false
    },
    "independence_reviewed": {
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      "ok": false
    },
    "primary_source_reviewed": {
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        "87f04a86-79ec-8449-b3ef-c72a3ae6c1c8",
        "9fc53ac2-428a-81d9-a2d4-5d8e33607e74"
      ],
      "ok": true
    }
  },
  "contradict_groups": 0,
  "rounding_boundary": false,
  "posterior_log_odds": "3.180961",
  "not_applicable_reason": null,
  "independence_unreviewed": 3
}