Claim

Model ledger-default@0.1.0 ledger-strict@0.1.0 ledger-default@0.2.0 ledger-strict@0.2.0 ledger-default@0.3.0 (default) ledger-strict@0.3.0 Snapshot seq

Topics

Biology · 1efd24fe Medicine · 1efd24fe

Assessment

Why?

Strongest counted support: The abstract reports elevated SRPX2, attenuation of injury and fibrosis after Srpx2 ablation, and the experimental models used. weight 2.000000 evidence

Suppressed as dependent: The excerpt directly reports elevated SRPX2 in CKD kidney biopsies and serum, upregulation in mouse fibrosis models and human tubular cells, and attenuation of kidney injury and fibrosis after global or tubular-epithelial Srpx2 ablation.

Review gaps: qualifiers reviewed, opposing search done, independence reviewed

What would most change this: One independent, direct measurement that contradicts this claim would move it from Supported to Leans supported.

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Checked as part of

Statements this claim was broken out of. The claim is scored on its own; a statement's reading only counts its claims.

• “SRPX2 expression was elevated in CKD patient kidney and serum samples and in experimental renal-fibrosis models, while global or tubular-epithelial deletion...” · 1 claim · 29 September 2026
• “A 2026 study found elevated SRPX2 in CKD patient kidney and serum samples and in mouse renal-fibrosis models; deleting Srpx2 attenuated kidney injury and...” · 2 claims · 29 September 2026

Evidence for

• The abstract reports elevated SRPX2, attenuation of injury and fibrosis after Srpx2 ablation, and the experimental models used.

  From Disruption of cellular iron homeostasis by SRPX2-IRP1 interaction aggravates renal fibrosis in chronic kidney disease Read 2026-09-29 Relevance DIRECT Steps 0 Counted

• A secondary scientific report corroborates elevated SRPX2 in CKD samples and attenuation of kidney injury and fibrosis after Srpx2 ablation in experimental models.

  From 苏州大学团队发现肾纤维化新轴：SRPX2劫持IRP1致铁失调 Read 2026-09-29 Relevance DIRECT Steps 0 Counted

• The excerpt directly reports elevated SRPX2 in CKD kidney biopsies and serum, upregulation in mouse fibrosis models and human tubular cells, and attenuation of kidney injury and fibrosis after global or tubular-epithelial Srpx2 ablation.

  From Disruption of cellular iron homeostasis by SRPX2-IRP1 interaction aggravates renal fibrosis in chronic kidney disease Read 2026-09-29 Relevance DIRECT Steps 0 Counted

  The passage matches the human-sample, experimental-model, deletion, injury, and fibrosis components.

Evidence against

None.

Qualifications

None.

Suppressed as dependent

Evidence	Group	Kept instead
0ef7907e		eb827f35

Inferences

Concluded from

None.

Used as a premise in

None.

An inference is interpretation, not evidence: it never changes the assessment of its conclusion. Each premise is a claim with its own evidence.

Threads

None. Threads are for disagreements about how a determination was made — a statement whose figures are not in the passage it rests on, two sources that may share an origin. Something about the world belongs in the evidence above.

Claim edges

None. Edges are stored and displayed; v0.1 does not propagate probability across them.

Review checklist

Review checks: 1 of 4

3 checks by this claim's own author, alongside the independent review above. 1 OPPOSING EVIDENCE SEARCH · 1 QUALIFIER CHECK · 1 EVIDENCE VERIFICATION. A check by the person who recorded a claim does not raise its review coverage.

Check	Done	By
qualifiers reviewed	no
opposing search done	no
independence reviewed	no
primary source reviewed	yes	eb827f35, 91093704

Summary

Contribution history

seq	event	detail
20475	APPENDED
20476	ACCEPT	AUTOMATIC_AFTER_VALIDATION
20487	LINK_EVIDENCE	by 1efd24fe (accepted)
20498	LINK_EVIDENCE	by 1efd24fe (accepted)
24104	TASK_RESULT	by 1efd24fe (accepted)

Score trace

{
  "claim": "438cb8c6-9dfe-8b3c-8782-d327a7ab7568",
  "links": [
    {
      "link": "195d45a4-5915-8cc2-b765-c28ceb827f35",
      "group": null,
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "27ab6380-5d71-8b46-b0b4-4bfd8c117e9b",
      "direction": "SUPPORT",
      "magnitude": "2.000000",
      "relevance": "DIRECT",
      "extraction": "UNVERIFIED",
      "provenance": "INDEPENDENT",
      "observation": "MEASUREMENT",
      "source_type": "PRIMARY_TEXT",
      "authenticity": "UNVERIFIED",
      "audit_confirmed": false,
      "effective_weight": "2.000000",
      "interpretive_steps": 0
    },
    {
      "kept": "195d45a4-5915-8cc2-b765-c28ceb827f35",
      "link": "6997c91f-cf6e-864f-a6b4-6eee91093704",
      "group": null,
      "reason": "dependent_strongest_only",
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "d33f7aff-b985-8ba8-b481-7d190ef7907e",
      "direction": "SUPPORT",
      "magnitude": "1.800000",
      "relevance": "DIRECT",
      "extraction": "UNVERIFIED",
      "provenance": "INDEPENDENT",
      "observation": "DIRECT_TEXT",
      "source_type": "PRIMARY_TEXT",
      "authenticity": "UNVERIFIED",
      "audit_confirmed": false,
      "effective_weight": "0.000000",
      "interpretive_steps": 0
    },
    {
      "link": "8f067667-c6d4-8546-901c-5f34cab3f6f6",
      "group": null,
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "1d95273e-2d21-8edd-8dc9-326e25078c35",
      "direction": "SUPPORT",
      "magnitude": "1.800000",
      "relevance": "DIRECT",
      "extraction": "UNVERIFIED",
      "provenance": "INDEPENDENT",
      "observation": "DIRECT_TEXT",
      "source_type": "SECONDARY_TEXT",
      "authenticity": "UNVERIFIED",
      "audit_confirmed": false,
      "effective_weight": "1.800000",
      "interpretive_steps": 0
    }
  ],
  "model": "ledger-default@0.3.0",
  "prior": "0.35",
  "variants": {
    "spread": "0.1019",
    "permissive": "0.9869",
    "conservative": "0.8850"
  },
  "code_hash": "sha256:c61a6fdf35a754a0d7e958df149036a083c0eaeb7d2d2e52704ec32b0c36def7",
  "contested": false,
  "stability": "LOW",
  "claim_type": "CAUSAL",
  "config_hash": "sha256:86768038080b8ab5233f1e4b7aba10af05b5bb44caa432095150b90e81209809",
  "probability": "0.9601",
  "provisional": true,
  "evidence_sum": "3.800000",
  "snapshot_seq": 25742,
  "prior_log_odds": "-0.619039",
  "support_groups": 2,
  "model_dependent": true,
  "review_coverage": "0.25",
  "truth_evaluable": true,
  "assessment_state": "SUPPORTED",
  "review_checklist": {
    "qualifiers_reviewed": {
      "by": [],
      "ok": false
    },
    "opposing_search_done": {
      "by": [],
      "ok": false
    },
    "independence_reviewed": {
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      "ok": false
    },
    "primary_source_reviewed": {
      "by": [
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        "6997c91f-cf6e-864f-a6b4-6eee91093704"
      ],
      "ok": true
    }
  },
  "contradict_groups": 0,
  "rounding_boundary": false,
  "posterior_log_odds": "3.180961",
  "not_applicable_reason": null,
  "independence_unreviewed": 3
}