Claim

The atlas analyzed postmortem dorsolateral prefrontal-cortex tissue from 1,384 PsychAD donors passing genotype and snRNA-seq quality control, including 493 non-European-ancestry donors (35.6%) across ages 0–108; its 14,258 gene-regulation findings are eGenes detected through multi-resolution eQTL analysis, with detection varying by cell-type abundance and subclass sample size.

Type QUANTITATIVE · truth-evaluable: yes · status at snapshot: ACTIVE · created seq 25461

46 words; atomic claims are usually under 25a conjunction joins clauses that may be separately evaluablea comma-separated series may list several propositions

Referenced 97 times: checked 0, looked up by assistants 0, viewed 97, shared 0. A count of attention, not evidence.

Topics

Not filed under any topic yet.

Assessment

Supported

Score: 0.9955 under ledger-default@0.3.0 at snapshot 27745

3 of 4 review checks done · 1 counted · 2 by the author only

3 independent evidence lineages · review checks 1 of 4 · stability HIGH

Main unresolved issue: 3 counted evidence items have no independence review; repeats of one origin may be counted as several coverage:5b7d0611-73f5-8494-9bf0-aea04e15ee2a

Not yet independently audited.Evidence reviewed so far supports this claim, but only 1 of 4 review checks has been done.

Related: NARROWS outgoing: Supported

Why?

Strongest counted support: The atlas used 5.6 million DLPFC nuclei from 1,384 diverse-ancestry PsychAD donors passing genotype and snRNA-seq quality control. weight 1.800000 evidence

Review gaps: qualifiers reviewed, opposing search done, independence reviewed

What would most change this: One independent, direct measurement that contradicts this claim would move it from Supported to Supported.

Hide calculation

0.9955 under ledger-default@0.3.0 at snapshot 27745 · state Supported · Review checks: 1 of 4 · stability HIGH · 3 sources, 3 independent lineages

Model ledger-default@0.3.0 (the default model, not the answer) · snapshot 27745 · trace sha256:70423b3e485a0e3d9d288549e32c8ce62ad4a4d567c54799bd75eb92378a2d9f

Last changed at entry seq 25467; nothing logged since has borne on this claim.

How the number was reached

Each counted link is weighed by multiplying the factors the model declares; a factor it does not declare is not shown. Every factor name below links to what that number means.

Link	Working	Weight	Counted as
5c2de646 support	relevance DIRECT 2.0 × observation DATASET_RESULT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	1.800000	1.800000
2e34e0f8 support	relevance DIRECT 2.0 × observation DIRECT_TEXT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	1.800000	1.800000
fbb3471f support	relevance DIRECT 2.0 × observation DIRECT_TEXT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	1.800000	1.800000

prior 0.50 → log-odds 0.000000 + 5.400000 (the counted weights) = 5.400000 → probability 0.9955

Under neighbouring settings of the same model: 0.9777 to 0.9991, a spread of 0.0214.

Half-even rounding, six places for weights and four for the probability. The same inputs under the same model reproduce this exactly; that is what the trace hash above is for. How a score is worked out explains every factor, why it is there, and what the model sets it to.

Your view

Registered views

Nobody has registered a view yet.

Registered views are personal belief, not evidence: they never change Galedra's assessment. Affiliations are self-declared and shown only for groups of 5 or more.

Evidence for

The atlas used 5.6 million DLPFC nuclei from 1,384 diverse-ancestry PsychAD donors passing genotype and snRNA-seq quality control.

From Single-nucleus atlas of cell-type specific genetic regulation in the human brain Read 2026-09-29 Relevance DIRECT Steps 0 Counted
The article reports 14,258 regulated genes across eight major classes and 27 subclasses.

From Single-nucleus atlas of cell-type specific genetic regulation in the human brain Read 2026-09-29 Relevance DIRECT Steps 0 Counted
eGene detection varies with cell abundance, and subclass resolution reduces power with smaller subclass sample sizes.

From Single-nucleus atlas of cell-type specific genetic regulation in the human brain Read 2026-09-29 Relevance DIRECT Steps 0 Counted

Evidence against

None.

Qualifications

None.

Suppressed as dependent

None.

Inferences

Concluded from

None.

Used as a premise in

None.

An inference is interpretation, not evidence: it never changes the assessment of its conclusion. Each premise is a claim with its own evidence.

Threads

None. Threads are for disagreements about how a determination was made — a statement whose figures are not in the passage it rests on, two sources that may share an origin. Something about the world belongs in the evidence above.

Claim edges

From	Relationship	To
4e15ee2a	NARROWS	ddba5235

Review checklist

Review checks: 1 of 4

2 checks by this claim's own author, alongside the independent review above. 1 OPPOSING EVIDENCE SEARCH · 1 QUALIFIER CHECK. A check by the person who recorded a claim does not raise its review coverage.

Check	Done	By
qualifiers reviewed	no
opposing search done	no
independence reviewed	no
primary source reviewed	yes	5c2de646, 2e34e0f8, fbb3471f

Summary

Supported. The main support is: The atlas used 5.6 million DLPFC nuclei from 1,384 diverse-ancestry PsychAD donors passing genotype and snRNA-seq quality control. 448c10d9

A search for evidence in the opposing direction found something; see the counted evidence. 367560fa

Review checks: 1 of 4. coverage:5b7d0611-73f5-8494-9bf0-aea04e15ee2a

Generated by stub-v0.1; every sentence cites graph ids.

Contribution history

seq	event	detail
25461	APPENDED
25462	ACCEPT	AUTOMATIC_AFTER_VALIDATION
25466	TASK_RESULT	by 1efd24fe (accepted)

Score trace

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  "claim": "5b7d0611-73f5-8494-9bf0-aea04e15ee2a",
  "links": [
    {
      "link": "50054d4d-effb-8274-9929-0c685c2de646",
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      "direction": "SUPPORT",
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      "relevance": "DIRECT",
      "extraction": "UNVERIFIED",
      "provenance": "INDEPENDENT",
      "observation": "DATASET_RESULT",
      "source_type": "PRIMARY_TEXT",
      "authenticity": "UNVERIFIED",
      "audit_confirmed": false,
      "effective_weight": "1.800000",
      "interpretive_steps": 0
    },
    {
      "link": "7d8ce874-fcee-843f-9076-de642e34e0f8",
      "group": null,
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    },
    {
      "link": "fea38969-4431-8522-ba34-87f9fbb3471f",
      "group": null,
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "133a4def-1125-843b-a67a-f8ebbd250423",
      "direction": "SUPPORT",
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      "relevance": "DIRECT",
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  ],
  "model": "ledger-default@0.3.0",
  "prior": "0.50",
  "variants": {
    "spread": "0.0214",
    "permissive": "0.9991",
    "conservative": "0.9777"
  },
  "code_hash": "sha256:c61a6fdf35a754a0d7e958df149036a083c0eaeb7d2d2e52704ec32b0c36def7",
  "contested": false,
  "stability": "HIGH",
  "claim_type": "QUANTITATIVE",
  "config_hash": "sha256:86768038080b8ab5233f1e4b7aba10af05b5bb44caa432095150b90e81209809",
  "probability": "0.9955",
  "provisional": true,
  "evidence_sum": "5.400000",
  "snapshot_seq": 25467,
  "prior_log_odds": "0.000000",
  "support_groups": 3,
  "model_dependent": false,
  "review_coverage": "0.25",
  "truth_evaluable": true,
  "assessment_state": "SUPPORTED",
  "review_checklist": {
    "qualifiers_reviewed": {
      "by": [],
      "ok": false
    },
    "opposing_search_done": {
      "by": [],
      "ok": false
    },
    "independence_reviewed": {
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      "ok": false
    },
    "primary_source_reviewed": {
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      ],
      "ok": true
    }
  },
  "contradict_groups": 0,
  "rounding_boundary": false,
  "posterior_log_odds": "5.400000",
  "not_applicable_reason": null,
  "independence_unreviewed": 3
}