Claim

Model ledger-default@0.1.0 ledger-strict@0.1.0 ledger-default@0.2.0 ledger-strict@0.2.0 ledger-default@0.3.0 (default) ledger-strict@0.3.0 Snapshot seq

Topics

Biology · 1efd24fe Medicine · 1efd24fe

Assessment

Why?

Strongest counted support: The abstract directly reports the later TLR- and CXCL2-dependent phase. weight 2.000000 evidence

Strongest counted contradiction: The primary article reports a later Pseudomonas phase requiring both CXCL1 and CXCL2, while MyD88 dependence does not uniquely identify TLR signaling. weight 0.540000 evidence

Suppressed as dependent: The excerpt directly reports that the later neutrophil-recruitment phase is TLR- and CXCL2-dependent and marks transition to the canonical pathogen-driven response.

Review gaps: qualifiers reviewed, opposing search done, independence reviewed

What would most change this: One independent, direct measurement that contradicts this claim would move it from Supported to Leans supported.

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Checked as part of

Statements this claim was broken out of. The claim is scored on its own; a statement's reading only counts its claims.

• “In the same skin-infection model, a later neutrophil-recruitment phase depended on Toll-like receptor and CXCL2 signaling, marking a transition to canonical...” · 1 claim · 29 September 2026
• “In a skin-infection model involving pathogenic bacteria and fungi, microbial adhesion to myeloid cells initiated an early innate-defense phase through...” · 2 claims · 29 September 2026

Evidence for

• The abstract directly reports the later TLR- and CXCL2-dependent phase.

  From Microbial adhesion promotes Piezo1 activation to initiate innate immunity Read 2026-09-29 Relevance DIRECT Steps 0 Counted

• A Nature Immunology research briefing corroborates the sequential transition from adhesion/Piezo1-driven early defense to later Toll-like receptor dominance in a mouse skin-infection model.

  From Dendritic cells sense microbial adhesion to launch innate immunity Read 2026-09-29 Relevance DIRECT Steps 0 Counted

• The excerpt directly reports that the later neutrophil-recruitment phase is TLR- and CXCL2-dependent and marks transition to the canonical pathogen-driven response.

  From Microbial adhesion promotes Piezo1 activation to initiate innate immunity Read 2026-09-29 Relevance DIRECT Steps 0 Counted

  The passage exactly matches the later-phase signaling and innate-immunity transition.

Evidence against

• The primary article reports a later Pseudomonas phase requiring both CXCL1 and CXCL2, while MyD88 dependence does not uniquely identify TLR signaling.

  From Microbial adhesion promotes Piezo1 activation to initiate innate immunity Read 2026-09-29 Relevance MODERATE Steps 0 Counted

  Qualifies any reading that the late recruitment phase is uniformly or exclusively TLR/CXCL2-dependent across the model’s pathogens.

Qualifications

None.

Suppressed as dependent

Evidence	Group	Kept instead
457bd9b1		38873ea2

Inferences

Concluded from

None.

Used as a premise in

None.

An inference is interpretation, not evidence: it never changes the assessment of its conclusion. Each premise is a claim with its own evidence.

Threads

None. Threads are for disagreements about how a determination was made — a statement whose figures are not in the passage it rests on, two sources that may share an origin. Something about the world belongs in the evidence above.

Claim edges

None. Edges are stored and displayed; v0.1 does not propagate probability across them.

Review checklist

Review checks: 1 of 4

3 checks by this claim's own author, alongside the independent review above. 1 OPPOSING EVIDENCE SEARCH · 1 QUALIFIER CHECK · 1 EVIDENCE VERIFICATION. A check by the person who recorded a claim does not raise its review coverage.

Check	Done	By
qualifiers reviewed	no
opposing search done	no
independence reviewed	no
primary source reviewed	yes	f06f5e1c, 38873ea2, c6e9d711

Summary

Contribution history

seq	event	detail
20067	APPENDED
20068	ACCEPT	AUTOMATIC_AFTER_VALIDATION
20077	LINK_EVIDENCE	by 1efd24fe (accepted)
20093	LINK_EVIDENCE	by 1efd24fe (accepted)
24027	TASK_RESULT	by 1efd24fe (accepted)
25737	TASK_RESULT	by 1efd24fe (accepted)

Score trace

{
  "claim": "6b8e3e0f-ea33-85f1-8908-46836048f43b",
  "links": [
    {
      "kept": "c7e44831-9770-8605-b57f-439f38873ea2",
      "link": "81c848d0-6084-85dc-b238-7362f06f5e1c",
      "group": null,
      "reason": "dependent_strongest_only",
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "afa304a2-a077-89dd-85b3-b21e457bd9b1",
      "direction": "SUPPORT",
      "magnitude": "1.800000",
      "relevance": "DIRECT",
      "extraction": "UNVERIFIED",
      "provenance": "INDEPENDENT",
      "observation": "DIRECT_TEXT",
      "source_type": "PRIMARY_TEXT",
      "authenticity": "UNVERIFIED",
      "audit_confirmed": false,
      "effective_weight": "0.000000",
      "interpretive_steps": 0
    },
    {
      "link": "b62cca86-15e3-8f61-a9d3-39a4de6378e6",
      "group": null,
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "0d8f4dbb-79b6-8e15-bf98-ea923db611b3",
      "direction": "SUPPORT",
      "magnitude": "1.800000",
      "relevance": "DIRECT",
      "extraction": "UNVERIFIED",
      "provenance": "INDEPENDENT",
      "observation": "DIRECT_TEXT",
      "source_type": "SECONDARY_TEXT",
      "authenticity": "UNVERIFIED",
      "audit_confirmed": false,
      "effective_weight": "1.800000",
      "interpretive_steps": 0
    },
    {
      "link": "c7e44831-9770-8605-b57f-439f38873ea2",
      "group": null,
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "d0c3b0d5-1f46-8682-b492-35e762b81e58",
      "direction": "SUPPORT",
      "magnitude": "2.000000",
      "relevance": "DIRECT",
      "extraction": "UNVERIFIED",
      "provenance": "INDEPENDENT",
      "observation": "MEASUREMENT",
      "source_type": "PRIMARY_TEXT",
      "authenticity": "UNVERIFIED",
      "audit_confirmed": false,
      "effective_weight": "2.000000",
      "interpretive_steps": 0
    },
    {
      "link": "d532c5ce-0097-8a96-a79e-7ac8c6e9d711",
      "group": null,
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "61bcb85d-cdac-8c71-a551-0a11d76f76ed",
      "direction": "CONTRADICT",
      "magnitude": "0.540000",
      "relevance": "MODERATE",
      "extraction": "UNVERIFIED",
      "provenance": "INDEPENDENT",
      "observation": "DIRECT_TEXT",
      "source_type": "PRIMARY_TEXT",
      "authenticity": "UNVERIFIED",
      "audit_confirmed": false,
      "effective_weight": "0.540000",
      "interpretive_steps": 0
    }
  ],
  "model": "ledger-default@0.3.0",
  "prior": "0.35",
  "variants": {
    "spread": "0.1333",
    "permissive": "0.9739",
    "conservative": "0.8406"
  },
  "code_hash": "sha256:c61a6fdf35a754a0d7e958df149036a083c0eaeb7d2d2e52704ec32b0c36def7",
  "contested": true,
  "stability": "LOW",
  "claim_type": "CAUSAL",
  "config_hash": "sha256:86768038080b8ab5233f1e4b7aba10af05b5bb44caa432095150b90e81209809",
  "probability": "0.9335",
  "provisional": true,
  "evidence_sum": "3.260000",
  "snapshot_seq": 25738,
  "prior_log_odds": "-0.619039",
  "support_groups": 2,
  "model_dependent": true,
  "review_coverage": "0.25",
  "truth_evaluable": true,
  "assessment_state": "SUPPORTED",
  "review_checklist": {
    "qualifiers_reviewed": {
      "by": [],
      "ok": false
    },
    "opposing_search_done": {
      "by": [],
      "ok": false
    },
    "independence_reviewed": {
      "by": [],
      "ok": false
    },
    "primary_source_reviewed": {
      "by": [
        "81c848d0-6084-85dc-b238-7362f06f5e1c",
        "c7e44831-9770-8605-b57f-439f38873ea2",
        "d532c5ce-0097-8a96-a79e-7ac8c6e9d711"
      ],
      "ok": true
    }
  },
  "contradict_groups": 1,
  "rounding_boundary": false,
  "posterior_log_odds": "2.640961",
  "not_applicable_reason": null,
  "independence_unreviewed": 4
}