Claim

In a murine MRSA infection model, IMP-2380 combined with ciprofloxacin produced a significant 100-fold reduction in bacterial burden, with three of five infections below the assay detection limit.

Type QUANTITATIVE · truth-evaluable: yes · status at snapshot: ACTIVE · created seq 18482

28 words; atomic claims are usually under 25a comma-separated series may list several propositions

Referenced 104 times: checked 1, looked up by assistants 0, viewed 81, shared 22. A count of attention, not evidence.

Topics

Medicine · 1efd24fe Public health · 1efd24fe

Assessment

Supported

Score: 0.8808 under ledger-default@0.3.0 at snapshot 27745

2 of 4 review checks done · 1 counted · 1 by the author only

1 independent evidence lineage · review checks 1 of 4 · stability MEDIUM

Main unresolved issue: 3 counted evidence items have no independence review; repeats of one origin may be counted as several coverage:032384d4-1b58-8477-87f4-c9d0561bde58

Not yet independently audited.Evidence reviewed so far supports this claim, but only 1 of 4 review checks has been done.A quoted passage from nature.com was not found on the page when Galedra fetched it.

Why?

Strongest counted support: The primary study reports a 100-fold bacterial-burden reduction in mice when IMP-2380 was combined with ciprofloxacin. weight 2.000000 evidence

Suppressed as dependent: The excerpt directly reports a significant 100-fold CFU reduction and three of five infections below assay detection.

Review gaps: qualifiers reviewed, opposing search done, independence reviewed

What would most change this: One independent, direct measurement that contradicts this claim would move it from Supported to Unresolved.

Hide calculation

0.8808 under ledger-default@0.3.0 at snapshot 27745 · state Supported · Review checks: 1 of 4 · stability MEDIUM · 3 sources, 1 independent lineage

Model ledger-default@0.3.0 (the default model, not the answer) · snapshot 27745 · trace sha256:23636eeb99ecb7e876ae3d3fcd873768583cd6f13099a77e8de588103eb7d23b

Last changed at entry seq 25888; nothing logged since has borne on this claim.

How the number was reached

Each counted link is weighed by multiplying the factors the model declares; a factor it does not declare is not shown. Every factor name below links to what that number means.

Link	Working	Weight	Counted as
4657c7d3 support	relevance DIRECT 2.0 × observation MEASUREMENT 1.0 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	2.000000	2.000000
54b5c672 support	relevance DIRECT 2.0 × observation DIRECT_TEXT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	1.800000	0.000000 (dependent strongest only, kept 4657c7d3)
7a0a5858 qualify	relevance DIRECT 2.0 × observation DIRECT_TEXT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	1.800000	0.000000 (non directional)

prior 0.50 → log-odds 0.000000 + 2.000000 (the counted weights) = 2.000000 → probability 0.8808

Under neighbouring settings of the same model: 0.8022 to 0.9309, a spread of 0.1287.

Half-even rounding, six places for weights and four for the probability. The same inputs under the same model reproduce this exactly; that is what the trace hash above is for. How a score is worked out explains every factor, why it is there, and what the model sets it to.

Your view

Registered views

Nobody has registered a view yet.

Registered views are personal belief, not evidence: they never change Galedra's assessment. Affiliations are self-declared and shown only for groups of 5 or more.

Checked as part of

Statements this claim was broken out of. The claim is scored on its own; a statement's reading only counts its claims.

“A 2026 study characterized IMP-2380 as a NorA efflux inhibitor that potentiated ciprofloxacin against MRSA and revealed its binding mode by cryo-EM.” · 2 claims · 29 September 2026

Evidence for

The primary study reports a 100-fold bacterial-burden reduction in mice when IMP-2380 was combined with ciprofloxacin.

From Small-molecule inhibitors block NorA efflux by conformational trapping Read 2026-09-29 Relevance DIRECT Steps 0 Counted

Primary murine infection-model result.
The excerpt directly reports a significant 100-fold CFU reduction and three of five infections below assay detection.

From Small-molecule inhibitors block NorA efflux by conformational trapping Read 2026-09-29 Relevance DIRECT Steps 0 Counted

Evidence against

None.

Qualifications

The 100-fold result was measured in young female C57BL/6 mice after a defined intraperitoneal inoculum, dosing schedule, and eight-hour endpoint.

From Small-molecule inhibitors block NorA efflux by conformational trapping Read 2026-09-29 Relevance DIRECT Steps 0 Counted

Suppressed as dependent

Evidence	Group	Kept instead
84e99aea		4657c7d3

Inferences

Concluded from

None.

Used as a premise in

None.

An inference is interpretation, not evidence: it never changes the assessment of its conclusion. Each premise is a claim with its own evidence.

Threads

None. Threads are for disagreements about how a determination was made — a statement whose figures are not in the passage it rests on, two sources that may share an origin. Something about the world belongs in the evidence above.

Claim edges

None. Edges are stored and displayed; v0.1 does not propagate probability across them.

Review checklist

Review checks: 1 of 4

2 checks by this claim's own author, alongside the independent review above. 1 QUALIFIER CHECK · 1 EVIDENCE VERIFICATION. A check by the person who recorded a claim does not raise its review coverage.

Check	Done	By
qualifiers reviewed	no
opposing search done	no
independence reviewed	no
primary source reviewed	yes	4657c7d3, 54b5c672, 7a0a5858

Summary

Supported. The main support is: The primary study reports a 100-fold bacterial-burden reduction in mice when IMP-2380 was combined with ciprofloxacin. 3b07a9b3

1 further item repeats the same origin and is not independent evidence. 84e99aea

Qualifier: The 100-fold result was measured in young female C57BL/6 mice after a defined intraperitoneal inoculum, dosing schedule, and eight-hour endpoint. ce658c8e

Review checks: 1 of 4. coverage:032384d4-1b58-8477-87f4-c9d0561bde58

Generated by stub-v0.1; every sentence cites graph ids.

Contribution history

seq	event	detail
18482	APPENDED
18483	ACCEPT	AUTOMATIC_AFTER_VALIDATION
18494	LINK_EVIDENCE	by 1efd24fe (accepted)
24715	TASK_RESULT	by 1efd24fe (accepted)
25887	TASK_RESULT	by 1efd24fe (accepted)

Score trace

{
  "claim": "032384d4-1b58-8477-87f4-c9d0561bde58",
  "links": [
    {
      "link": "1f43d993-849b-8e59-a15d-a9654657c7d3",
      "group": null,
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "5515ab0e-8942-87e3-8bf1-89513b07a9b3",
      "direction": "SUPPORT",
      "magnitude": "2.000000",
      "relevance": "DIRECT",
      "extraction": "UNVERIFIED",
      "provenance": "INDEPENDENT",
      "observation": "MEASUREMENT",
      "source_type": "PRIMARY_TEXT",
      "authenticity": "UNVERIFIED",
      "audit_confirmed": false,
      "effective_weight": "2.000000",
      "interpretive_steps": 0
    },
    {
      "kept": "1f43d993-849b-8e59-a15d-a9654657c7d3",
      "link": "68b125e6-5093-832b-8cc9-30e654b5c672",
      "group": null,
      "reason": "dependent_strongest_only",
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "6a4209e0-6bb9-8203-843c-d35d84e99aea",
      "direction": "SUPPORT",
      "magnitude": "1.800000",
      "relevance": "DIRECT",
      "extraction": "UNVERIFIED",
      "provenance": "INDEPENDENT",
      "observation": "DIRECT_TEXT",
      "source_type": "PRIMARY_TEXT",
      "authenticity": "UNVERIFIED",
      "audit_confirmed": false,
      "effective_weight": "0.000000",
      "interpretive_steps": 0
    },
    {
      "link": "788bf35c-1c42-811e-ba16-9f777a0a5858",
      "group": null,
      "reason": "non_directional",
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "3f34dfb0-bbbc-8116-a4cd-090fce658c8e",
      "direction": "QUALIFY",
      "magnitude": "1.800000",
      "relevance": "DIRECT",
      "extraction": "UNVERIFIED",
      "provenance": "INDEPENDENT",
      "observation": "DIRECT_TEXT",
      "source_type": "PRIMARY_TEXT",
      "authenticity": "UNVERIFIED",
      "audit_confirmed": false,
      "effective_weight": "0.000000",
      "interpretive_steps": 0
    }
  ],
  "model": "ledger-default@0.3.0",
  "prior": "0.50",
  "variants": {
    "spread": "0.1287",
    "permissive": "0.9309",
    "conservative": "0.8022"
  },
  "code_hash": "sha256:c61a6fdf35a754a0d7e958df149036a083c0eaeb7d2d2e52704ec32b0c36def7",
  "contested": false,
  "stability": "MEDIUM",
  "claim_type": "QUANTITATIVE",
  "config_hash": "sha256:86768038080b8ab5233f1e4b7aba10af05b5bb44caa432095150b90e81209809",
  "probability": "0.8808",
  "provisional": true,
  "evidence_sum": "2.000000",
  "snapshot_seq": 25888,
  "prior_log_odds": "0.000000",
  "support_groups": 1,
  "model_dependent": false,
  "review_coverage": "0.25",
  "truth_evaluable": true,
  "assessment_state": "SUPPORTED",
  "review_checklist": {
    "qualifiers_reviewed": {
      "by": [],
      "ok": false
    },
    "opposing_search_done": {
      "by": [],
      "ok": false
    },
    "independence_reviewed": {
      "by": [],
      "ok": false
    },
    "primary_source_reviewed": {
      "by": [
        "1f43d993-849b-8e59-a15d-a9654657c7d3",
        "68b125e6-5093-832b-8cc9-30e654b5c672",
        "788bf35c-1c42-811e-ba16-9f777a0a5858"
      ],
      "ok": true
    }
  },
  "contradict_groups": 0,
  "rounding_boundary": false,
  "posterior_log_odds": "2.000000",
  "not_applicable_reason": null,
  "independence_unreviewed": 3
}