Claim

In a massively parallel reporter assay of human neural progenitor cells, researchers tested 9,092 cortical-structure-associated variants and reported regulatory potential for 918 variants from 150 loci, representing 76% of loci studied; more than half showed allelic effects.

Type QUANTITATIVE · truth-evaluable: yes · status at snapshot: ACTIVE · created seq 14811 · qualifiers {"population":"Human neural progenitor cells in an episomal massively parallel reporter assay; the result does not by itself establish endogenous chromatin effects or causal effects on cortical structure."}

37 words; atomic claims are usually under 25a conjunction joins clauses that may be separately evaluablea comma-separated series may list several propositions

Referenced 83 times: checked 2, looked up by assistants 0, viewed 53, shared 28. A count of attention, not evidence.

Topics

Neuroscience · 1efd24fe Biology · 1efd24fe

Assessment

Supported

Score: 0.9781 under ledger-default@0.3.0 at snapshot 27745

2 of 4 review checks done · 1 counted · 1 by the author only

2 independent evidence lineages · review checks 1 of 4 · stability HIGH

Main unresolved issue: 3 counted evidence items have no independence review; repeats of one origin may be counted as several coverage:3cd47199-67c2-8cf6-8c96-571091933119

Not yet independently audited.Evidence reviewed so far supports this claim, but only 1 of 4 review checks has been done.Every quoted passage was confirmed on the page when Galedra fetched it.

Why?

Strongest counted support: The abstract reports the tested variant count, regulatory-potential count, locus coverage, allelic effects, and Wnt-dependent enhancer finding. weight 2.000000 evidence

Suppressed as dependent: The excerpt directly reports the tested variants, regulatory-potential variants, locus coverage, and allelic-effect proportion.

Review gaps: qualifiers reviewed, opposing search done, independence reviewed

What would most change this: One independent, direct measurement that contradicts this claim would move it from Supported to Supported.

Hide calculation

0.9781 under ledger-default@0.3.0 at snapshot 27745 · state Supported · Review checks: 1 of 4 · stability HIGH · 3 sources, 2 independent lineages

Model ledger-default@0.3.0 (the default model, not the answer) · snapshot 27745 · trace sha256:740e1ebd6a534c993d7dc3b5d49f21deb18d81f2787df0df6d48c7c5e76295de

Last changed at entry seq 16835; nothing logged since has borne on this claim.

How the number was reached

Each counted link is weighed by multiplying the factors the model declares; a factor it does not declare is not shown. Every factor name below links to what that number means.

Link	Working	Weight	Counted as
9c99c08f support	relevance DIRECT 2.0 × observation MEASUREMENT 1.0 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	2.000000	2.000000
9215f203 support	relevance DIRECT 2.0 × observation MEASUREMENT 1.0 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	2.000000	0.000000 (dependent strongest only, kept 9c99c08f)
8c709ed0 support	relevance DIRECT 2.0 × observation DIRECT_TEXT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	1.800000	1.800000

prior 0.50 → log-odds 0.000000 + 3.800000 (the counted weights) = 3.800000 → probability 0.9781

Under neighbouring settings of the same model: 0.9346 to 0.9929, a spread of 0.0583.

Half-even rounding, six places for weights and four for the probability. The same inputs under the same model reproduce this exactly; that is what the trace hash above is for. How a score is worked out explains every factor, why it is there, and what the model sets it to.

Your view

Registered views

Nobody has registered a view yet.

Registered views are personal belief, not evidence: they never change Galedra's assessment. Affiliations are self-declared and shown only for groups of 5 or more.

Checked as part of

Statements this claim was broken out of. The claim is scored on its own; a statement's reading only counts its claims.

“In a massively parallel reporter assay of human neural progenitor cells, researchers tested 9,092 cortical-structure-associated variants and reported...” · 1 claim · 29 September 2026
“A 2026 Nature Neuroscience MPRA study tested cortical-structure-associated variants in human neural progenitor cells and found regulatory and Wnt-dependent...” · 2 claims · 28 September 2026

Evidence for

The abstract reports the tested variant count, regulatory-potential count, locus coverage, allelic effects, and Wnt-dependent enhancer finding.

From Massively parallel assessment of gene regulatory activity at human cortical-structure-associated variants Read 2026-09-28 Relevance DIRECT Steps 0 Counted

The abstract directly states the quantitative elements of the claim.
The excerpt directly reports the tested variants, regulatory-potential variants, locus coverage, and allelic-effect proportion.

From Massively parallel assessment of gene regulatory activity at human cortical-structure-associated variants Read 2026-09-28 Relevance DIRECT Steps 0 Counted

The passage explicitly states every quantitative element of the claim.
The primary Nature Neuroscience study directly reports the tested variant count, regulatory-potential count, locus share, and allelic-effect result.

From Massively parallel assessment of gene regulatory activity at human cortical-structure-associated variants Read 2026-09-29 Relevance DIRECT Steps 0 Counted

Primary peer-reviewed study; distinct neuroscience/genetics topic.

Evidence against

None.

Qualifications

None.

Suppressed as dependent

Evidence	Group	Kept instead
decc2ed4		9c99c08f

Inferences

Concluded from

None.

Used as a premise in

None.

An inference is interpretation, not evidence: it never changes the assessment of its conclusion. Each premise is a claim with its own evidence.

Threads

None. Threads are for disagreements about how a determination was made — a statement whose figures are not in the passage it rests on, two sources that may share an origin. Something about the world belongs in the evidence above.

Claim edges

None. Edges are stored and displayed; v0.1 does not propagate probability across them.

Review checklist

Review checks: 1 of 4

2 checks by this claim's own author, alongside the independent review above. 1 QUALIFIER CHECK · 1 EVIDENCE VERIFICATION. A check by the person who recorded a claim does not raise its review coverage.

Check	Done	By
qualifiers reviewed	no
opposing search done	no
independence reviewed	no
primary source reviewed	yes	9c99c08f, 9215f203, 8c709ed0

Summary

Supported. The main support is: The abstract reports the tested variant count, regulatory-potential count, locus coverage, allelic effects, and Wnt-dependent enhancer finding. 75097b26

1 further item repeats the same origin and is not independent evidence. decc2ed4

Review checks: 1 of 4. coverage:3cd47199-67c2-8cf6-8c96-571091933119

Generated by stub-v0.1; every sentence cites graph ids.

Contribution history

seq	event	detail
14811	APPENDED
14812	ACCEPT	AUTOMATIC_AFTER_VALIDATION
14823	LINK_EVIDENCE	by 1efd24fe (accepted)
14827	TASK_RESULT	by 1efd24fe (accepted)
16834	LINK_EVIDENCE	by 1efd24fe (accepted)

Score trace

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  "claim": "3cd47199-67c2-8cf6-8c96-571091933119",
  "links": [
    {
      "link": "a9ed8f84-13b0-80a4-8cb0-5a039c99c08f",
      "group": null,
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "db7ef3ef-46fc-8a4c-b297-5bda75097b26",
      "direction": "SUPPORT",
      "magnitude": "2.000000",
      "relevance": "DIRECT",
      "extraction": "UNVERIFIED",
      "provenance": "INDEPENDENT",
      "observation": "MEASUREMENT",
      "source_type": "PRIMARY_TEXT",
      "authenticity": "UNVERIFIED",
      "audit_confirmed": false,
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    {
      "kept": "a9ed8f84-13b0-80a4-8cb0-5a039c99c08f",
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      "group": null,
      "reason": "dependent_strongest_only",
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "0ec9e403-3587-827b-9263-ae5cdecc2ed4",
      "direction": "SUPPORT",
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      "extraction": "UNVERIFIED",
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      "authenticity": "UNVERIFIED",
      "audit_confirmed": false,
      "effective_weight": "0.000000",
      "interpretive_steps": 0
    },
    {
      "link": "e69302f3-180d-88ab-908e-4b228c709ed0",
      "group": null,
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "01ccd99c-7de7-8609-a00f-cbf26b5536f0",
      "direction": "SUPPORT",
      "magnitude": "1.800000",
      "relevance": "DIRECT",
      "extraction": "UNVERIFIED",
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      "source_type": "PRIMARY_TEXT",
      "authenticity": "UNVERIFIED",
      "audit_confirmed": false,
      "effective_weight": "1.800000",
      "interpretive_steps": 0
    }
  ],
  "model": "ledger-default@0.3.0",
  "prior": "0.50",
  "variants": {
    "spread": "0.0583",
    "permissive": "0.9929",
    "conservative": "0.9346"
  },
  "code_hash": "sha256:c61a6fdf35a754a0d7e958df149036a083c0eaeb7d2d2e52704ec32b0c36def7",
  "contested": false,
  "stability": "HIGH",
  "claim_type": "QUANTITATIVE",
  "config_hash": "sha256:86768038080b8ab5233f1e4b7aba10af05b5bb44caa432095150b90e81209809",
  "probability": "0.9781",
  "provisional": true,
  "evidence_sum": "3.800000",
  "snapshot_seq": 16835,
  "prior_log_odds": "0.000000",
  "support_groups": 2,
  "model_dependent": false,
  "review_coverage": "0.25",
  "truth_evaluable": true,
  "assessment_state": "SUPPORTED",
  "review_checklist": {
    "qualifiers_reviewed": {
      "by": [],
      "ok": false
    },
    "opposing_search_done": {
      "by": [],
      "ok": false
    },
    "independence_reviewed": {
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      "ok": false
    },
    "primary_source_reviewed": {
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        "e69302f3-180d-88ab-908e-4b228c709ed0"
      ],
      "ok": true
    }
  },
  "contradict_groups": 0,
  "rounding_boundary": false,
  "posterior_log_odds": "3.800000",
  "not_applicable_reason": null,
  "independence_unreviewed": 3
}