Claim

Model ledger-default@0.1.0 ledger-strict@0.1.0 ledger-default@0.2.0 ledger-strict@0.2.0 ledger-default@0.3.0 (default) ledger-strict@0.3.0 Snapshot seq

Topics

Neuroscience · 1efd24fe Medicine · 1efd24fe

Assessment

Why?

Strongest counted support: The preprint describes a randomized double-blind crossover trial of 37 biomarker-confirmed early Alzheimer disease patients. weight 1.800000 evidence

Suppressed as dependent: The excerpt directly reports a randomized double-blind placebo-controlled crossover trial of 37 biomarker-confirmed early Alzheimer patients over one night versus sham.

Review gaps: qualifiers reviewed, opposing search done, independence reviewed

What would most change this: One independent, direct measurement that contradicts this claim would move it from Supported to Unresolved.

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Checked as part of

Statements this claim was broken out of. The claim is scored on its own; a statement's reading only counts its claims.

• “A randomized double-blind crossover preprint studied closed-loop auditory stimulation during sleep in 37 patients with biomarker-confirmed early Alzheimer...” · 3 claims · 29 September 2026

Evidence for

• The preprint describes a randomized double-blind crossover trial of 37 biomarker-confirmed early Alzheimer disease patients.

  From One night of closed-loop auditory stimulation during sleep enhances memory consolidation in patients with Alzheimer’s Disease Read 2026-09-29 Relevance DIRECT Steps 0 Counted

• The excerpt directly reports a randomized double-blind placebo-controlled crossover trial of 37 biomarker-confirmed early Alzheimer patients over one night versus sham.

  From One night of closed-loop auditory stimulation during sleep enhances memory consolidation in patients with Alzheimer’s Disease Read 2026-09-29 Relevance DIRECT Steps 0 Counted

Evidence against

None.

Qualifications

• The trial tests acute one-night effects in a selected Spanish early-AD sample; analyzed denominators differ by outcome, and the abstract-level benefit does not establish durable seven-day efficacy.

  From One night of closed-loop auditory stimulation during sleep enhances memory consolidation in patients with Alzheimer’s Disease Read 2026-09-29 Relevance DIRECT Steps 0 Counted

  Adds age, language, jurisdiction, screening/enrollment/analysis denominators, washout, outcome-specific denominator, and durability limitation.

Suppressed as dependent

Evidence	Group	Kept instead
d75e2edd		10c7de67

Inferences

Concluded from

None.

Used as a premise in

None.

An inference is interpretation, not evidence: it never changes the assessment of its conclusion. Each premise is a claim with its own evidence.

Threads

None. Threads are for disagreements about how a determination was made — a statement whose figures are not in the passage it rests on, two sources that may share an origin. Something about the world belongs in the evidence above.

Claim edges

None. Edges are stored and displayed; v0.1 does not propagate probability across them.

Review checklist

Review checks: 1 of 4

2 checks by this claim's own author, alongside the independent review above. 1 QUALIFIER CHECK · 1 EVIDENCE VERIFICATION. A check by the person who recorded a claim does not raise its review coverage.

Check	Done	By
qualifiers reviewed	no
opposing search done	no
independence reviewed	no
primary source reviewed	yes	1e3ed663, 10c7de67, 5eb7e401

Summary

Contribution history

seq	event	detail
23358	APPENDED
23359	ACCEPT	AUTOMATIC_AFTER_VALIDATION
23376	LINK_EVIDENCE	by 1efd24fe (accepted)
24620	TASK_RESULT	by 1efd24fe (accepted)
25697	TASK_RESULT	by 1efd24fe (accepted)

Score trace

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  "claim": "4714e89e-53f9-8840-ae21-81155392800c",
  "links": [
    {
      "kept": "9d0c48ba-18a4-8e55-abe2-9d8f10c7de67",
      "link": "89c6a7d7-85d5-8b55-a57b-e04c1e3ed663",
      "group": null,
      "reason": "dependent_strongest_only",
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "f74119f8-8c45-814a-aad5-0605d75e2edd",
      "direction": "SUPPORT",
      "magnitude": "1.800000",
      "relevance": "DIRECT",
      "extraction": "UNVERIFIED",
      "provenance": "INDEPENDENT",
      "observation": "DIRECT_TEXT",
      "source_type": "PRIMARY_TEXT",
      "authenticity": "UNVERIFIED",
      "audit_confirmed": false,
      "effective_weight": "0.000000",
      "interpretive_steps": 0
    },
    {
      "link": "9d0c48ba-18a4-8e55-abe2-9d8f10c7de67",
      "group": null,
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "135ddcbf-2723-858c-868e-765903e57c88",
      "direction": "SUPPORT",
      "magnitude": "1.800000",
      "relevance": "DIRECT",
      "extraction": "UNVERIFIED",
      "provenance": "INDEPENDENT",
      "observation": "DATASET_RESULT",
      "source_type": "PRIMARY_TEXT",
      "authenticity": "UNVERIFIED",
      "audit_confirmed": false,
      "effective_weight": "1.800000",
      "interpretive_steps": 0
    },
    {
      "link": "e186fed0-93bb-8074-9099-75b25eb7e401",
      "group": null,
      "reason": "non_directional",
      "edition": "NAMED_OR_UNRELATED",
      "evidence": "8f3611a5-ea3a-8191-9a49-070a14226c1e",
      "direction": "QUALIFY",
      "magnitude": "2.000000",
      "relevance": "DIRECT",
      "extraction": "UNVERIFIED",
      "provenance": "INDEPENDENT",
      "observation": "MEASUREMENT",
      "source_type": "PRIMARY_TEXT",
      "authenticity": "UNVERIFIED",
      "audit_confirmed": false,
      "effective_weight": "0.000000",
      "interpretive_steps": 0
    }
  ],
  "model": "ledger-default@0.3.0",
  "prior": "0.50",
  "variants": {
    "spread": "0.1331",
    "permissive": "0.9121",
    "conservative": "0.7790"
  },
  "code_hash": "sha256:c61a6fdf35a754a0d7e958df149036a083c0eaeb7d2d2e52704ec32b0c36def7",
  "contested": false,
  "stability": "MEDIUM",
  "claim_type": "QUANTITATIVE",
  "config_hash": "sha256:86768038080b8ab5233f1e4b7aba10af05b5bb44caa432095150b90e81209809",
  "probability": "0.8581",
  "provisional": true,
  "evidence_sum": "1.800000",
  "snapshot_seq": 25698,
  "prior_log_odds": "0.000000",
  "support_groups": 1,
  "model_dependent": false,
  "review_coverage": "0.25",
  "truth_evaluable": true,
  "assessment_state": "SUPPORTED",
  "review_checklist": {
    "qualifiers_reviewed": {
      "by": [],
      "ok": false
    },
    "opposing_search_done": {
      "by": [],
      "ok": false
    },
    "independence_reviewed": {
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      "ok": false
    },
    "primary_source_reviewed": {
      "by": [
        "89c6a7d7-85d5-8b55-a57b-e04c1e3ed663",
        "9d0c48ba-18a4-8e55-abe2-9d8f10c7de67",
        "e186fed0-93bb-8074-9099-75b25eb7e401"
      ],
      "ok": true
    }
  },
  "contradict_groups": 0,
  "rounding_boundary": false,
  "posterior_log_odds": "1.800000",
  "not_applicable_reason": null,
  "independence_unreviewed": 3
}