Claim

In the study, hindbrain activity was necessary for mesenteric-artery constriction and gut blood-flow reduction during hypoxia in zebrafish.

Type CAUSAL · truth-evaluable: yes · status at snapshot: ACTIVE · created seq 22158

a conjunction joins clauses that may be separately evaluable

Referenced 113 times: checked 2, looked up by assistants 0, viewed 72, shared 39. A count of attention, not evidence.

Topics

Biology · 1efd24fe Neuroscience · 1efd24fe

Assessment

Supported

Score: 0.9729 under ledger-default@0.3.0 at snapshot 27745

3 of 4 review checks done · 1 counted · 2 by the author only

3 independent evidence lineages · review checks 1 of 4 · stability LOW

Main unresolved issue: 6 counted evidence items have no independence review; repeats of one origin may be counted as several coverage:b96c0cbe-3189-83db-b371-ebbc8c6d9727

Not yet independently audited.This assessment depends heavily on modeling choices.Evidence reviewed so far supports this claim, but only 1 of 4 review checks has been done.A quoted passage from nature.com was not found on the page when Galedra fetched it.

Why?

Strongest counted support: The perturbation experiment reports hypoxia-specific gut-flow loss and restoration after hindbrain inhibition, supporting the stated causal relationship. weight 1.800000 evidence

Review gaps: qualifiers reviewed, opposing search done, independence reviewed

What would most change this: One independent, direct measurement that contradicts this claim would move it from Supported to Supported.

Hide calculation

0.9729 under ledger-default@0.3.0 at snapshot 27745 · state Supported · Review checks: 1 of 4 · stability LOW · 6 sources, 3 independent lineages

Model ledger-default@0.3.0 (the default model, not the answer) · snapshot 27745 · trace sha256:c635e6a221757e55e7f82d10da65de00ac94e5d9ba69937196be097a2c2f33ca

Last changed at entry seq 24429; nothing logged since has borne on this claim.

How the number was reached

Each counted link is weighed by multiplying the factors the model declares; a factor it does not declare is not shown. Every factor name below links to what that number means.

Link	Working	Weight	Counted as
239906b6 qualify	relevance DIRECT 2.0 × observation DIRECT_TEXT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	1.800000	0.000000 (non directional)
7c927210 support	relevance DIRECT 2.0 × observation EXPERT_ANALYSIS 0.3 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	0.600000	0.600000
49e7ed5c qualify	relevance DIRECT 2.0 × observation DIRECT_TEXT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	1.800000	0.000000 (non directional)
ed01ace8 qualify	relevance DIRECT 2.0 × observation DIRECT_TEXT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	1.800000	0.000000 (non directional)
30edc1c5 support	relevance DIRECT 2.0 × observation DIRECT_TEXT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	1.800000	1.800000
9afb9c65 support	relevance DIRECT 2.0 × observation DIRECT_TEXT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	1.800000	1.800000

prior 0.35 → log-odds -0.619039 + 4.200000 (the counted weights) = 3.580961 → probability 0.9729

Under neighbouring settings of the same model: 0.9106 to 0.9922, a spread of 0.0816.

Half-even rounding, six places for weights and four for the probability. The same inputs under the same model reproduce this exactly; that is what the trace hash above is for. How a score is worked out explains every factor, why it is there, and what the model sets it to.

Your view

Registered views

Nobody has registered a view yet.

Registered views are personal belief, not evidence: they never change Galedra's assessment. Affiliations are self-declared and shown only for groups of 5 or more.

Checked as part of

Statements this claim was broken out of. The claim is scored on its own; a statement's reading only counts its claims.

“In the study, hindbrain activity was necessary for mesenteric-artery constriction and gut blood-flow reduction during hypoxia in zebrafish.” · 1 claim · 29 September 2026
“A 2026 Nature study introduced WHOLISTIC for cellular-resolution imaging of body-wide physiology in transparent vertebrates.” · 3 claims · 29 September 2026

Evidence for

The primary study reports a causal requirement for hindbrain activity in hypoxic mesenteric constriction.

From Imaging cellular activity across all organs reveals body-wide circuits Read 2026-09-29 Relevance DIRECT Steps 0 Counted

Exact conclusion from optogenetic perturbation.
The perturbation experiment reports hypoxia-specific gut-flow loss and restoration after hindbrain inhibition, supporting the stated causal relationship.

From Imaging cellular activity across all organs reveals body-wide circuits Read 2026-09-29 Relevance DIRECT Steps 0 Counted

Direct optogenetic perturbation result.
Optogenetic hindbrain inhibition restored gut blood flow during hypoxia, and the authors conclude hindbrain activity is necessary for mesenteric-artery constriction.

From Imaging cellular activity across all organs reveals body-wide circuits Read 2026-09-29 Relevance DIRECT Steps 0 Counted

The primary article reports the causal perturbation and conclusion.

Evidence against

None.

Qualifications

The supplied passage directly supports hindbrain activity being necessary for hypoxic mesenteric-artery constriction, but it does not mention gut blood-flow reduction.

From Imaging cellular activity across all organs reveals body-wide circuits Read 2026-09-29 Relevance DIRECT Steps 0 Counted

The excerpt supports the constriction component while leaving the added gut-blood-flow component unaddressed.
The primary study documents near-complete cessation of gut blood flow during hypoxia and recovery with normoxia.

From Imaging cellular activity across all organs reveals body-wide circuits Read 2026-09-29 Relevance DIRECT Steps 0 Counted

Adds the missing hypoxic gut-blood-flow endpoint and its normoxic recovery context.
The primary study reports that hindbrain inhibition restored gut blood flow within seconds during hypoxia, with a control-location comparison.

From Imaging cellular activity across all organs reveals body-wide circuits Read 2026-09-29 Relevance DIRECT Steps 0 Counted

Adds the causal hindbrain-inhibition condition and rapid restoration of gut flow.

Suppressed as dependent

None.

Inferences

Concluded from

None.

Used as a premise in

None.

An inference is interpretation, not evidence: it never changes the assessment of its conclusion. Each premise is a claim with its own evidence.

Threads

None. Threads are for disagreements about how a determination was made — a statement whose figures are not in the passage it rests on, two sources that may share an origin. Something about the world belongs in the evidence above.

Claim edges

None. Edges are stored and displayed; v0.1 does not propagate probability across them.

Review checklist

Review checks: 1 of 4

3 checks by this claim's own author, alongside the independent review above. 1 OPPOSING EVIDENCE SEARCH · 1 QUALIFIER CHECK · 1 EVIDENCE VERIFICATION. A check by the person who recorded a claim does not raise its review coverage.

Check	Done	By
qualifiers reviewed	no
opposing search done	no
independence reviewed	no
primary source reviewed	yes	239906b6, 7c927210, 49e7ed5c, ed01ace8, 30edc1c5, 9afb9c65

Summary

Supported. The main support is: The primary study reports a causal requirement for hindbrain activity in hypoxic mesenteric constriction. f1d769a9

Qualifier: The primary study reports that hindbrain inhibition restored gut blood flow within seconds during hypoxia, with a control-location comparison. 341bfe1f

Qualifier: The supplied passage directly supports hindbrain activity being necessary for hypoxic mesenteric-artery constriction, but it does not mention gut blood-flow reduction. ab853227

Qualifier: The primary study documents near-complete cessation of gut blood flow during hypoxia and recovery with normoxia. 7923c01c

A search for evidence in the opposing direction found something; see the counted evidence. 9dfe1281

Review checks: 1 of 4. coverage:b96c0cbe-3189-83db-b371-ebbc8c6d9727

Generated by stub-v0.1; every sentence cites graph ids.

Contribution history

seq	event	detail
22158	APPENDED
22159	ACCEPT	AUTOMATIC_AFTER_VALIDATION
22172	LINK_EVIDENCE	by 1efd24fe (accepted)
22176	TASK_RESULT	by 1efd24fe (accepted)
22222	LINK_EVIDENCE	by 1efd24fe (accepted)
23835	TASK_RESULT	by 1efd24fe (accepted)
24428	TASK_RESULT	by 1efd24fe (accepted)

Score trace

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