Claim

In a nationwide prospective Swedish cohort of 181 children with acute leukemia, a three-pronged phenotyping and sequencing strategy identified pathogenic germline alterations in 9 patients (5.0%); 8 of 9 received tailored surveillance and 4 of 9 had treatment modifications.

Type QUANTITATIVE · truth-evaluable: yes · status at snapshot: ACTIVE · created seq 17695

39 words; atomic claims are usually under 25a conjunction joins clauses that may be separately evaluable

Referenced 110 times: checked 1, looked up by assistants 0, viewed 79, shared 30. A count of attention, not evidence.

Topics

Medicine · 1efd24fe Health · 1efd24fe

Assessment

Supported

Score: 0.8581 under ledger-default@0.3.0 at snapshot 27745

2 of 4 review checks done · 1 counted · 1 by the author only

1 independent evidence lineage · review checks 1 of 4 · stability MEDIUM

Main unresolved issue: 5 counted evidence items have no independence review; repeats of one origin may be counted as several coverage:ca36c392-5071-88e6-ab5f-bef21fba5fff

Not yet independently audited.Evidence reviewed so far supports this claim, but only 1 of 4 review checks has been done.Every quoted passage was confirmed on the page when Galedra fetched it.

Why?

Strongest counted support: The Swedish cohort found pathogenic germline alterations in 9 of 181 children, with tailored surveillance for eight and treatment modifications for four. weight 1.800000 evidence

Suppressed as dependent: The packet directly supports the 181-patient cohort, nine pathogenic germline findings, and surveillance and treatment actions.

Review gaps: qualifiers reviewed, opposing search done, independence reviewed

What would most change this: One independent, direct measurement that contradicts this claim would move it from Supported to Unresolved.

Hide calculation

0.8581 under ledger-default@0.3.0 at snapshot 27745 · state Supported · Review checks: 1 of 4 · stability MEDIUM · 5 sources, 1 independent lineage

Model ledger-default@0.3.0 (the default model, not the answer) · snapshot 27745 · trace sha256:fbd9ed6fd817b33bb4319bfb85ada5e495ce41fab0b2ed9f32460c26fbe9682b

Last changed at entry seq 25357; nothing logged since has borne on this claim.

How the number was reached

Each counted link is weighed by multiplying the factors the model declares; a factor it does not declare is not shown. Every factor name below links to what that number means.

Link	Working	Weight	Counted as
317d439b support	relevance DIRECT 2.0 × observation DATASET_RESULT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	1.800000	1.800000
c1e4dd82 qualify	relevance DIRECT 2.0 × observation DIRECT_TEXT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	1.800000	0.000000 (non directional)
610a9742 qualify	relevance DIRECT 2.0 × observation MEASUREMENT 1.0 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	2.000000	0.000000 (non directional)
6aee44a0 support	relevance DIRECT 2.0 × observation DATASET_RESULT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	1.800000	0.000000 (dependent strongest only, kept 317d439b)
94dbfb22 qualify	relevance DIRECT 2.0 × observation DIRECT_TEXT 0.9 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	1.800000	0.000000 (non directional)

prior 0.50 → log-odds 0.000000 + 1.800000 (the counted weights) = 1.800000 → probability 0.8581

Under neighbouring settings of the same model: 0.7790 to 0.9121, a spread of 0.1331.

Half-even rounding, six places for weights and four for the probability. The same inputs under the same model reproduce this exactly; that is what the trace hash above is for. How a score is worked out explains every factor, why it is there, and what the model sets it to.

Your view

Registered views

Nobody has registered a view yet.

Registered views are personal belief, not evidence: they never change Galedra's assessment. Affiliations are self-declared and shown only for groups of 5 or more.

Checked as part of

Statements this claim was broken out of. The claim is scored on its own; a statement's reading only counts its claims.

“In a nationwide prospective Swedish cohort of 181 children with acute leukemia, a three-pronged phenotyping and sequencing strategy identified pathogenic...” · 1 claim · 29 September 2026

Evidence for

The Swedish cohort found pathogenic germline alterations in 9 of 181 children, with tailored surveillance for eight and treatment modifications for four.

From Diagnostic yield of cancer predisposition in a nationwide prospective childhood acute leukemia cohort Read 2026-09-29 Relevance DIRECT Steps 0 Counted
The packet directly supports the 181-patient cohort, nine pathogenic germline findings, and surveillance and treatment actions.

From Diagnostic yield of cancer predisposition in a nationwide prospective childhood acute leukemia cohort Read 2026-09-29 Relevance DIRECT Steps 0 Counted

Evidence against

None.

Qualifications

The study covered Swedish children aged 0–17 enrolled across six centers from December 2021 through April 2024.

From Diagnostic yield of cancer predisposition in a nationwide prospective childhood acute leukemia cohort Read 2026-09-29 Relevance DIRECT Steps 0 Counted

Adds study dates, age range, and six-center Swedish scope.
The 5% yield combines six established leukemia-predisposition cases with three solid-tumor-predisposition findings not established as leukemia causes.

From Diagnostic yield of cancer predisposition in a nationwide prospective childhood acute leukemia cohort Read 2026-09-29 Relevance DIRECT Steps 0 Counted

Separates leukemia-predisposition from solid-tumor-predisposition findings within the nine.
The 181-patient cohort did not include all 213 registry diagnoses because consent and logistics limited enrollment.

From Diagnostic yield of cancer predisposition in a nationwide prospective childhood acute leukemia cohort Read 2026-09-29 Relevance DIRECT Steps 0 Counted

Records the enrollment-coverage limitation relative to registry diagnoses.

Suppressed as dependent

Evidence	Group	Kept instead
a7a61d42		317d439b

Inferences

Concluded from

None.

Used as a premise in

None.

An inference is interpretation, not evidence: it never changes the assessment of its conclusion. Each premise is a claim with its own evidence.

Threads

None. Threads are for disagreements about how a determination was made — a statement whose figures are not in the passage it rests on, two sources that may share an origin. Something about the world belongs in the evidence above.

Claim edges

None. Edges are stored and displayed; v0.1 does not propagate probability across them.

Review checklist

Review checks: 1 of 4

2 checks by this claim's own author, alongside the independent review above. 1 QUALIFIER CHECK · 1 EVIDENCE VERIFICATION. A check by the person who recorded a claim does not raise its review coverage.

Check	Done	By
qualifiers reviewed	no
opposing search done	no
independence reviewed	no
primary source reviewed	yes	317d439b, c1e4dd82, 610a9742, 6aee44a0, 94dbfb22

Summary

Supported. The main support is: The Swedish cohort found pathogenic germline alterations in 9 of 181 children, with tailored surveillance for eight and treatment modifications for four. 243ec54c

1 further item repeats the same origin and is not independent evidence. a7a61d42

Qualifier: The 181-patient cohort did not include all 213 registry diagnoses because consent and logistics limited enrollment. cb069268

Qualifier: The 5% yield combines six established leukemia-predisposition cases with three solid-tumor-predisposition findings not established as leukemia causes. eb00c4b3

Qualifier: The study covered Swedish children aged 0–17 enrolled across six centers from December 2021 through April 2024. 1f2ce07d

Review checks: 1 of 4. coverage:ca36c392-5071-88e6-ab5f-bef21fba5fff

Generated by stub-v0.1; every sentence cites graph ids.

Contribution history

seq	event	detail
17695	APPENDED
17696	ACCEPT	AUTOMATIC_AFTER_VALIDATION
17701	LINK_EVIDENCE	by 1efd24fe (accepted)
17735	TASK_RESULT	by 1efd24fe (accepted)
25356	TASK_RESULT	by 1efd24fe (accepted)

Score trace

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