Claim

In the study's MPRA, Wnt stimulation increased activity for 32 elements, vehicle conditions increased activity for 7, and 12 variants showed significant condition-dependent allelic effects.

Type QUANTITATIVE · truth-evaluable: yes · status at snapshot: ACTIVE · created seq 14815 · qualifiers {"population":"The reported counts are from the study's human neural progenitor-cell MPRA and its FDR \u003c 0.1 condition-dependent analyses."}

a conjunction joins clauses that may be separately evaluablea comma-separated series may list several propositions

Referenced 87 times: checked 1, looked up by assistants 0, viewed 65, shared 21. A count of attention, not evidence.

Topics

Neuroscience · 1efd24fe Biology · 1efd24fe

Assessment

Supported

Score: 0.8808 under ledger-default@0.3.0 at snapshot 27745

2 of 4 review checks done · 1 counted · 1 by the author only

1 independent evidence lineage · review checks 1 of 4 · stability MEDIUM

Main unresolved issue: 2 counted evidence items have no independence review; repeats of one origin may be counted as several coverage:ec7d1281-edad-80b8-aa86-813d584a4cab

Not yet independently audited.Evidence reviewed so far supports this claim, but only 1 of 4 review checks has been done.A quoted passage from nature.com was not found on the page when Galedra fetched it.

Why?

Strongest counted support: The results report 32 Wnt-enhanced elements, 7 vehicle-enhanced elements, and 12 condition-dependent allelic variants. weight 2.000000 evidence

Suppressed as dependent: The excerpt directly reports the 32 Wnt-enhanced elements, 7 vehicle-enhanced elements, and 12 condition-dependent variants.

Review gaps: qualifiers reviewed, opposing search done, independence reviewed

What would most change this: One independent, direct measurement that contradicts this claim would move it from Supported to Unresolved.

Hide calculation

0.8808 under ledger-default@0.3.0 at snapshot 27745 · state Supported · Review checks: 1 of 4 · stability MEDIUM · 2 sources, 1 independent lineage

Model ledger-default@0.3.0 (the default model, not the answer) · snapshot 27745 · trace sha256:788af0a7f906132e155fa4fedcf79ca214a99f3381c4ade6db54f7145ffd8b27

Last changed at entry seq 15600; nothing logged since has borne on this claim.

How the number was reached

Each counted link is weighed by multiplying the factors the model declares; a factor it does not declare is not shown. Every factor name below links to what that number means.

Link	Working	Weight	Counted as
26cb961f support	relevance DIRECT 2.0 × observation MEASUREMENT 1.0 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	2.000000	2.000000
81299243 support	relevance DIRECT 2.0 × observation MEASUREMENT 1.0 × interpretation 0 steps, 1 − 0.15 × 0 1.000000 × authenticity UNVERIFIED 1.0 × extraction UNVERIFIED 1.0 × provenance INDEPENDENT 1.0 × edition NAMED_OR_UNRELATED 1	2.000000	0.000000 (dependent strongest only, kept 26cb961f)

prior 0.50 → log-odds 0.000000 + 2.000000 (the counted weights) = 2.000000 → probability 0.8808

Under neighbouring settings of the same model: 0.8022 to 0.9309, a spread of 0.1287.

Half-even rounding, six places for weights and four for the probability. The same inputs under the same model reproduce this exactly; that is what the trace hash above is for. How a score is worked out explains every factor, why it is there, and what the model sets it to.

Your view

Registered views

Nobody has registered a view yet.

Registered views are personal belief, not evidence: they never change Galedra's assessment. Affiliations are self-declared and shown only for groups of 5 or more.

Checked as part of

Statements this claim was broken out of. The claim is scored on its own; a statement's reading only counts its claims.

“A 2026 Nature Neuroscience MPRA study tested cortical-structure-associated variants in human neural progenitor cells and found regulatory and Wnt-dependent...” · 2 claims · 28 September 2026

Evidence for

The results report 32 Wnt-enhanced elements, 7 vehicle-enhanced elements, and 12 condition-dependent allelic variants.

From Massively parallel assessment of gene regulatory activity at human cortical-structure-associated variants Read 2026-09-28 Relevance DIRECT Steps 0 Counted

The results passage directly states each count and the significance threshold for condition-dependent variants.
The excerpt directly reports the 32 Wnt-enhanced elements, 7 vehicle-enhanced elements, and 12 condition-dependent variants.

From Massively parallel assessment of gene regulatory activity at human cortical-structure-associated variants Read 2026-09-28 Relevance DIRECT Steps 0 Counted

The passage explicitly states each count and the FDR threshold for condition-dependent variants.

Evidence against

None.

Qualifications

None.

Suppressed as dependent

Evidence	Group	Kept instead
d8c5f772		26cb961f

Inferences

Concluded from

None.

Used as a premise in

None.

An inference is interpretation, not evidence: it never changes the assessment of its conclusion. Each premise is a claim with its own evidence.

Threads

None. Threads are for disagreements about how a determination was made — a statement whose figures are not in the passage it rests on, two sources that may share an origin. Something about the world belongs in the evidence above.

Claim edges

None. Edges are stored and displayed; v0.1 does not propagate probability across them.

Review checklist

Review checks: 1 of 4

2 checks by this claim's own author, alongside the independent review above. 1 QUALIFIER CHECK · 1 EVIDENCE VERIFICATION. A check by the person who recorded a claim does not raise its review coverage.

Check	Done	By
qualifiers reviewed	no
opposing search done	no
independence reviewed	no
primary source reviewed	yes	26cb961f, 81299243

Summary

Supported. The main support is: The results report 32 Wnt-enhanced elements, 7 vehicle-enhanced elements, and 12 condition-dependent allelic variants. f0292653

1 further item repeats the same origin and is not independent evidence. d8c5f772

Review checks: 1 of 4. coverage:ec7d1281-edad-80b8-aa86-813d584a4cab

Generated by stub-v0.1; every sentence cites graph ids.

Contribution history

seq	event	detail
14815	APPENDED
14816	ACCEPT	AUTOMATIC_AFTER_VALIDATION
14825	LINK_EVIDENCE	by 1efd24fe (accepted)
14829	TASK_RESULT	by 1efd24fe (accepted)

Score trace

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      "group": null,
      "reason": "dependent_strongest_only",
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    }
  ],
  "model": "ledger-default@0.3.0",
  "prior": "0.50",
  "variants": {
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    "permissive": "0.9309",
    "conservative": "0.8022"
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  "code_hash": "sha256:c61a6fdf35a754a0d7e958df149036a083c0eaeb7d2d2e52704ec32b0c36def7",
  "contested": false,
  "stability": "MEDIUM",
  "claim_type": "QUANTITATIVE",
  "config_hash": "sha256:86768038080b8ab5233f1e4b7aba10af05b5bb44caa432095150b90e81209809",
  "probability": "0.8808",
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  "evidence_sum": "2.000000",
  "snapshot_seq": 15600,
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  "support_groups": 1,
  "model_dependent": false,
  "review_coverage": "0.25",
  "truth_evaluable": true,
  "assessment_state": "SUPPORTED",
  "review_checklist": {
    "qualifiers_reviewed": {
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    },
    "opposing_search_done": {
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    "independence_reviewed": {
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    },
    "primary_source_reviewed": {
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      ],
      "ok": true
    }
  },
  "contradict_groups": 0,
  "rounding_boundary": false,
  "posterior_log_odds": "2.000000",
  "not_applicable_reason": null,
  "independence_unreviewed": 2
}