Claim

Model ledger-default@0.1.0 ledger-strict@0.1.0 ledger-default@0.2.0 ledger-strict@0.2.0 ledger-default@0.3.0 (default) ledger-strict@0.3.0 Snapshot seq

Topics

Biology · 1efd24fe Medicine · 1efd24fe

Assessment

Why?

Strongest counted support: The abstract reports SRPX2–IRP1 interaction, disrupted iron homeostasis, and benefit from iron dextran in the UUO model. weight 2.000000 evidence

Suppressed as dependent: The excerpt directly reports SRPX2 interaction with IRP1, resulting iron dyshomeostasis, and alleviation of UUO-induced renal fibrosis by iron dextran.

Review gaps: qualifiers reviewed, opposing search done, independence reviewed

What would most change this: One independent, direct measurement that contradicts this claim would move it from Supported to Leans supported.

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Checked as part of

Statements this claim was broken out of. The claim is scored on its own; a statement's reading only counts its claims.

• “In experimental renal fibrosis, SRPX2 interacted with IRP1 and disrupted iron-regulatory signaling, and iron dextran supplementation alleviated UUO-induced...” · 1 claim · 29 September 2026
• “A 2026 study found elevated SRPX2 in CKD patient kidney and serum samples and in mouse renal-fibrosis models; deleting Srpx2 attenuated kidney injury and...” · 2 claims · 29 September 2026

Evidence for

• The abstract reports SRPX2–IRP1 interaction, disrupted iron homeostasis, and benefit from iron dextran in the UUO model.

  From Disruption of cellular iron homeostasis by SRPX2-IRP1 interaction aggravates renal fibrosis in chronic kidney disease Read 2026-09-29 Relevance DIRECT Steps 0 Counted

• A secondary scientific report corroborates the SRPX2–IRP1 interaction, disrupted iron regulation, and reduced UUO-induced fibrosis after therapeutic iron-dextran supplementation.

  From 苏州大学团队发现肾纤维化新轴：SRPX2劫持IRP1致铁失调 Read 2026-09-29 Relevance DIRECT Steps 0 Counted

• The excerpt directly reports SRPX2 interaction with IRP1, resulting iron dyshomeostasis, and alleviation of UUO-induced renal fibrosis by iron dextran.

  From Disruption of cellular iron homeostasis by SRPX2-IRP1 interaction aggravates renal fibrosis in chronic kidney disease Read 2026-09-29 Relevance DIRECT Steps 0 Counted

  The passage exactly supports the interaction, signaling disruption, and mouse intervention components.

Evidence against

None.

Qualifications

• The study uses mouse and HK-2 cell models, while iron-dextran benefit is specifically reported for UUO-induced fibrosis.

  From Disruption of cellular iron homeostasis by SRPX2-IRP1 interaction aggravates renal fibrosis in chronic kidney disease Read 2026-09-29 Relevance DIRECT Steps 0 Counted

  The intervention result should not be generalized from UUO mice to the folic-acid model, HK-2 cells, or clinical treatment.

Suppressed as dependent

Evidence	Group	Kept instead
8ba9bfed		1c831e04

Inferences

Concluded from

None.

Used as a premise in

None.

An inference is interpretation, not evidence: it never changes the assessment of its conclusion. Each premise is a claim with its own evidence.

Threads

None. Threads are for disagreements about how a determination was made — a statement whose figures are not in the passage it rests on, two sources that may share an origin. Something about the world belongs in the evidence above.

Claim edges

None. Edges are stored and displayed; v0.1 does not propagate probability across them.

Review checklist

Review checks: 1 of 4

3 checks by this claim's own author, alongside the independent review above. 1 OPPOSING EVIDENCE SEARCH · 1 QUALIFIER CHECK · 1 EVIDENCE VERIFICATION. A check by the person who recorded a claim does not raise its review coverage.

Check	Done	By
qualifiers reviewed	no
opposing search done	no
independence reviewed	no
primary source reviewed	yes	5f146af8, 1c831e04, 66cb979f

Summary

Contribution history

seq	event	detail
20479	APPENDED
20480	ACCEPT	AUTOMATIC_AFTER_VALIDATION
20489	LINK_EVIDENCE	by 1efd24fe (accepted)
20504	LINK_EVIDENCE	by 1efd24fe (accepted)
24106	TASK_RESULT	by 1efd24fe (accepted)
25015	TASK_RESULT	by 1efd24fe (accepted)

Score trace

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  "model": "ledger-default@0.3.0",
  "prior": "0.35",
  "variants": {
    "spread": "0.1019",
    "permissive": "0.9869",
    "conservative": "0.8850"
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  "code_hash": "sha256:c61a6fdf35a754a0d7e958df149036a083c0eaeb7d2d2e52704ec32b0c36def7",
  "contested": false,
  "stability": "LOW",
  "claim_type": "CAUSAL",
  "config_hash": "sha256:86768038080b8ab5233f1e4b7aba10af05b5bb44caa432095150b90e81209809",
  "probability": "0.9601",
  "provisional": true,
  "evidence_sum": "3.800000",
  "snapshot_seq": 25744,
  "prior_log_odds": "-0.619039",
  "support_groups": 2,
  "model_dependent": true,
  "review_coverage": "0.25",
  "truth_evaluable": true,
  "assessment_state": "SUPPORTED",
  "review_checklist": {
    "qualifiers_reviewed": {
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    "opposing_search_done": {
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  "contradict_groups": 0,
  "rounding_boundary": false,
  "posterior_log_odds": "3.180961",
  "not_applicable_reason": null,
  "independence_unreviewed": 4
}